Document Detail


Bradykinin B(2) receptor antagonism attenuates blood pressure response to acute angiotensin-converting enzyme inhibition in normal men.
MedLine Citation:
PMID:  10904025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physiological effects of angiotensin-converting enzyme (ACE) inhibition may be in part mediated by bradykinin. We investigated the effect of coadministration of the specific bradykinin B(2) receptor antagonist icatibant on hemodynamic and neurohormonal responses to acute intravenous ACE inhibition in normal men on a normal sodium diet. We performed a 4-phase, double-blind, double-dummy, placebo-controlled study in 12 male volunteers. The bradykinin antagonist icatibant (10 mg IV) was coadministered over the first 15 minutes of a 2-hour infusion of the ACE inhibitor perindoprilat (1.5 mg IV). Perindoprilat inhibited ACE activity and elicited the expected changes in active renin concentration and angiotensin peptides. Over the 3 hours after the start of drug infusion, perindoprilat lowered and icatibant increased mean arterial blood pressure (each P<0.0005 versus placebo). Coadministration of icatibant attenuated the mean arterial blood pressure response to perindoprilat (P<0.0005) but had no effect on neurohormonal responses to perindoprilat. Our study indicates that the bradykinin B(2) receptor antagonist icatibant attenuates the short-term blood pressure-lowering effect of acute ACE inhibition in normal men on a normal sodium diet. Bradykinin B(2) receptor antagonism alone increases resting blood pressure. Bradykinin may be involved in the control of blood pressure in the resting state in humans.
Authors:
I B Squire; K P O'Kane; N Anderson; J L Reid
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  36     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-10-06     Completed Date:  2000-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  132-6     Citation Subset:  IM    
Affiliation:
Department of Medicine & Therapeutics, University of Glasgow, Glasgow, Scotland. 11@le.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Angiotensins / blood
Area Under Curve
Blood Pressure / drug effects*
Bradykinin / analogs & derivatives*,  pharmacology,  physiology
Double-Blind Method
Humans
Male
Peptidyl-Dipeptidase A / blood
Receptor, Bradykinin B2
Receptors, Bradykinin / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Angiotensins; 0/Receptor, Bradykinin B2; 0/Receptors, Bradykinin; 130308-48-4/icatibant; 58-82-2/Bradykinin; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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