Document Detail

Bradycardia with sevoflurane induction in patients with trisomy 21.
MedLine Citation:
PMID:  12846713     Owner:  NLM     Status:  MEDLINE    
The authors present a series of three paediatric patients with trisomy 21 who developed significant bradycardia during inhalation induction with sevoflurane. All three were undergoing adenotonsillectomy. The possible association of such problems with trisomy 21 and treatment options are reviewed. Although the occurrence of bradycardia in these three patients may have been a random occurrence, given its occurrence in three of five consecutive patients with trisomy 21, a causal relationship may be involved and future observation of these patients appears warranted.
Steve Roodman; Marcella Bothwell; Joseph D Tobias
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  13     ISSN:  1155-5645     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-08     Completed Date:  2003-11-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  538-40     Citation Subset:  IM    
Department of Anesthesiology, The University of Missouri, Columbia, MO, USA.
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MeSH Terms
Anesthesia, Inhalation / adverse effects*
Anesthetics, Inhalation / adverse effects*
Bradycardia / chemically induced*,  physiopathology
Child, Preschool
Down Syndrome / complications*
Methyl Ethers / adverse effects*
Retrospective Studies
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Methyl Ethers; 28523-86-6/sevoflurane

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