Document Detail


Bradycardia induced by irinotecan: a case report.
MedLine Citation:
PMID:  9861240     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Irinotecan chloride (CPT-11) is a new semi-synthetic camptothecin analogue which has encouraging antitumor activity against various malignancies. The major and unique toxicity of CPT-11 is diarrhea. Cardiovascular toxicity is rare and has not been found in clinical trials performed in Japan except for a very few cases of insignificant tachycardiac arrhythmia. We report a case of a 69-year-old man with recurrent colon cancer who suffered from bradycardia induced by infusion of CPT-11. Other toxicities including hematological toxicity and diarrhea were mild. Pharmacokinetic analysis using a limited sampling model revealed that the occurrence of bradycardia did not correlate with the excess of drug exposure. Although all of the cholinergic actions reported in the literature were mild, cardiotoxicity may come to be a clinically significant problem. If the events were examined more thoroughly, the cholinergic effect may be discovered more frequently. To administer CPT-11 safely needs meticulous monitoring not only for hematological toxicity and diarrhea but also for other cholinergic actions including bradycardia.
Authors:
T Miya; R Fujikawa; J Fukushima; H Nogami; Y Koshiishi; T Goya
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese journal of clinical oncology     Volume:  28     ISSN:  0368-2811     ISO Abbreviation:  Jpn. J. Clin. Oncol.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-12-23     Completed Date:  1998-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0313225     Medline TA:  Jpn J Clin Oncol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  709-11     Citation Subset:  IM    
Affiliation:
Department of Surgery II, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. toshimichi@mtg.biglobe.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Antineoplastic Agents, Phytogenic / adverse effects*,  pharmacokinetics
Bradycardia / chemically induced*
Camptothecin / adverse effects,  analogs & derivatives*,  pharmacokinetics
Cholinergic Agents / adverse effects
Colonic Neoplasms / drug therapy,  metabolism
Diarrhea / chemically induced
Electrocardiography
Humans
Male
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Cholinergic Agents; 100286-90-6/irinotecan; 7689-03-4/Camptothecin

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