Document Detail


Brachyury expression predicts poor prognosis at early stages of colorectal cancer.
MedLine Citation:
PMID:  21220197     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although survival rates of colon cancer patients diagnosed at an early stage (T1-2N0M0; Dukes A) vary considerably according to the studies cited, several studies indicate development of distant metastases already occurring in a considerable percentage of these patients leading to the death of the patients. This particular high risk group cannot be identified properly as no marker exists to identify these patients. As the Wnt/Win pathway plays a crucial role in metastasis formation in colorectal carcinoma, we analysed whether the transcription factor brachyury critically involved in this pathway may predict metastasis formation in these patients. The expression of brachyury-homologous (T) was immunohistochemically analysed in 748 patients and the data were correlated with classical and newer prognostic markers in colorectal cancer. Early stages colorectal cancer patients (T1-2N0M0, Dukes A) showed a significantly decreased survival when brachyury was expressed in the tumour tissue while no correlation was observed in later tumour stages. Hence a subset of colorectal cancers exists in which the ability to metastasise is already present at early stages of tumour growth and this high risk group can now be detected by immunohistochemistry.
Authors:
Nerbil Kilic; Susanne Feldhaus; Ergin Kilic; Pierre Tennstedt; Daniel Wicklein; Reinhard von Wasielewski; Christoph Viebahn; Hans Kreipe; Udo Schumacher
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-8
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  -     ISSN:  1879-0852     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Internal Medicine II: Oncology/Haematology, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany.
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