Document Detail


Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ.
MedLine Citation:
PMID:  23155121     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brachytherapy is a common clinical technique involving implantation of sealed radioactive "seeds" within a tumor to selectively irradiate the tumor mass while minimizing systemic toxicity. To mitigate the disadvantages associated with complex surgical implantation and subsequent device removal procedures, we have developed an alternative approach using a genetically encoded peptide polymer solution composed of a thermally responsive elastin-like polypeptide (ELP) radiolabeled with (131)I that self-assembles into radionuclide seeds upon intratumoral injection. The formation of these nontoxic and biodegradable polymer seeds led to prolonged intratumoral retention (~85% ID/tumor 7 days postinjection) of the radionuclide, elicited a tumor growth delay in 100% of the tumors in two human xenografts (FaDu and PC-3), and cured more than 67% of tumor-bearing animals after a single administration of labeled ELP. These results suggest that in situ self-assembly of biodegradable and injectable radionuclide-containing polypeptide seeds could be a promising therapeutic alternative to conventional brachytherapy.
Authors:
Wenge Liu; Jonathan McDaniel; Xinghai Li; Daisuke Asai; Felipe Garcia Quiroz; Jeffery Schaal; Ji Sun Park; Michael Zalutsky; Ashutosh Chilkoti
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cancer research     Volume:  72     ISSN:  1538-7445     ISO Abbreviation:  Cancer Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-03-05     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5956-65     Citation Subset:  IM    
Copyright Information:
©2012 AACR.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brachytherapy / methods*
Carcinoma, Squamous Cell / genetics,  radiotherapy*
Cell Line, Tumor
Drug Delivery Systems
Elastin / administration & dosage,  chemistry*,  genetics
Female
Humans
Hypopharyngeal Neoplasms / genetics,  radiotherapy*
Iodine Radioisotopes / administration & dosage*
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Peptides / administration & dosage*,  chemical synthesis,  chemistry,  genetics
Prostatic Neoplasms / genetics,  radiotherapy*
Tandem Repeat Sequences
Xenograft Model Antitumor Assays
Grant Support
ID/Acronym/Agency:
5R01CA138784-03/CA/NCI NIH HHS; R01 CA138784/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Peptides; 9007-58-3/Elastin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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