| Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ. | |
| | |
MedLine Citation:
|
PMID: 23155121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Brachytherapy is a common clinical technique involving implantation of sealed radioactive "seeds" within a tumor to selectively irradiate the tumor mass while minimizing systemic toxicity. To mitigate the disadvantages associated with complex surgical implantation and subsequent device removal procedures, we have developed an alternative approach using a genetically encoded peptide polymer solution composed of a thermally responsive elastin-like polypeptide (ELP) radiolabeled with (131)I that self-assembles into radionuclide seeds upon intratumoral injection. The formation of these nontoxic and biodegradable polymer seeds led to prolonged intratumoral retention (~85% ID/tumor 7 days postinjection) of the radionuclide, elicited a tumor growth delay in 100% of the tumors in two human xenografts (FaDu and PC-3), and cured more than 67% of tumor-bearing animals after a single administration of labeled ELP. These results suggest that in situ self-assembly of biodegradable and injectable radionuclide-containing polypeptide seeds could be a promising therapeutic alternative to conventional brachytherapy. |
| | |
Authors:
|
Wenge Liu; Jonathan McDaniel; Xinghai Li; Daisuke Asai; Felipe Garcia Quiroz; Jeffery Schaal; Ji Sun Park; Michael Zalutsky; Ashutosh Chilkoti |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Cancer research Volume: 72 ISSN: 1538-7445 ISO Abbreviation: Cancer Res. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-16 Completed Date: 2013-03-05 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
|
Languages: eng Pagination: 5956-65 Citation Subset: IM |
Copyright Information:
|
©2012 AACR. |
Affiliation:
|
Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. wengeliu@duke.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brachytherapy / methods* Carcinoma, Squamous Cell / genetics, radiotherapy* Cell Line, Tumor Drug Delivery Systems Elastin / administration & dosage, chemistry*, genetics Female Humans Hypopharyngeal Neoplasms / genetics, radiotherapy* Iodine Radioisotopes / administration & dosage* Male Mice Mice, Inbred BALB C Mice, Nude Peptides / administration & dosage*, chemical synthesis, chemistry, genetics Prostatic Neoplasms / genetics, radiotherapy* Tandem Repeat Sequences Xenograft Model Antitumor Assays |
| Grant Support | |
ID/Acronym/Agency:
|
5R01CA138784-03/CA/NCI NIH HHS; R01 CA138784/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Iodine Radioisotopes; 0/Peptides; 9007-58-3/Elastin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Decomposed and non-decomposed bodies retrieved from water: a comparative approach.
Next Document: Menstrual Phase and Depressive Symptoms Differences in Physiological Response to Nicotine Following ...