Document Detail


Brachycephaly and frontal lobe hypoplasia in fetuses with trisomy 21 at 11 + 0 to 13 + 6 weeks.
MedLine Citation:
PMID:  17086579     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the incidence of brachycephaly and frontal lobe hypoplasia in fetuses with trisomy 21 at 11 + 0 to 13 + 6 weeks of gestation. METHODS: A three-dimensional (3D) volume of the fetal head was obtained before fetal karyotyping at 11 + 0 to 13 + 6 (median, 12 + 5) weeks of gestation in 100 fetuses that were subsequently found to have trisomy 21 and in 300 fetuses subsequently found to be chromosomally normal. The multiplanar mode was used to obtain a sequence of transverse views of the fetal head and to demonstrate the biparietal and suboccipitobregmatic views. We measured the biparietal diameter (BPD), the occipitofrontal diameter (OFD) and the frontothalamic distance (FTD) between the inner table of the frontal bone and the posterior thalami. RESULTS: In the chromosomally normal group the BPD, OFD and FTD increased linearly with crown-rump length (CRL) from 16.7 mm, 19.0 mm and 12.1 mm at a CRL of 45 mm to 26.7 mm, 31.7 mm and 18.7 mm, respectively, at a CRL of 84 mm. In the trisomy 21 fetuses, compared to normal fetuses, there was shorter BPD (mean difference = -0.63 mm; 95% CI, -0.97 to -0.30 mm, P < 0.0001), OFD (mean difference = -1.41 mm; 95% CI, -1.75 to -1.07 mm, P < 0.0001) and FTD (mean difference = -0.77 mm; 95% CI, -1.02 to -0.54 mm; P < 0.0001) and higher BPD to OFD ratio (mean difference = 0.022; 95% CI, 0.012 to 0.032, P < 0.0001) but no significant difference in the FTD to OFD ratio (mean difference = 0.004; 95% CI, -0.006 to 0.013, P = 0.448). CONCLUSIONS: In fetuses with trisomy 21 at 11 + 0 to 13 + 6 weeks of gestation there is evidence of brachycephaIy but not of frontal lobe hypoplasia.
Authors:
M Borenstein; T Dagklis; B Csapo; A Sotiriadis; K H Nicolaides
Related Documents :
24488859 - Minimally invasive therapy for fetal sacrococcygeal teratomas: case series and systemat...
14634979 - Ductus venosus assessment at the time of nuchal translucency measurement in the detecti...
11536259 - The effect of fetal gender on nuchal translucency at 10-14 weeks of gestation.
7788489 - First-trimester ultrasound screening for fetal aneuploidies in women over 35 and under ...
17300689 - Fronto-nasal dysplasia and atrio-ventricular canal in a fetus with trisomy 18 identifie...
19797009 - Prenatal sonographic features of fetuses in trisomy 13 pregnancies (ii).
18166769 - An unusual hotspot in a young woman with hodgkin's lymphoma.
16702269 - Embryo survival from gossypol-fed heifers after transfer to lactating cows treated with...
16893459 - The role of urine pregnancy testing in facilitating access to antenatal care and aborti...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  28     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-29     Completed Date:  2007-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  870-5     Citation Subset:  IM    
Copyright Information:
Copyright 2006 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child, Preschool
Diagnosis
Female
Frontal Lobe / abnormalities*,  ultrasonography
Gestational Age
Humans
Infant
Infant, Newborn
Male
Microcephaly / genetics,  ultrasonography*
Middle Aged
Pregnancy
Trisomy / diagnosis,  genetics*
Ultrasonography, Prenatal / instrumentation,  methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Right aortic arch detected in fetal life.
Next Document:  Associated and predictive factors of sleep disturbance in advanced cancer patients.