Document Detail

Brachial artery hyperaemic blood flow velocity in relation to established indices of vascular function and global atherosclerosis: The Prospective Investigation of the Vasculature in Uppsala Seniors study.
MedLine Citation:
PMID:  22487158     Owner:  NLM     Status:  In-Data-Review    
Background:  Systolic to diastolic blood flow velocity (SDFV) ratio in the brachial artery recently proved to be related to cardiovascular risk and carotid atherosclerosis. We hypothesized that the SDFV ratio was related to established markers of vascular function and global atherosclerosis. Methods:  Established markers of endothelial function in forearm resistance vessels, flow-mediated vasodilation and arterial stiffness were assessed in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study including 1016 individuals aged 70. Whole-body magnetic resonance angiography was performed in a random 306 of the participants. Atherosclerotic lesions were summarized in a total atherosclerotic score (TAS). Before and during hyperaemia of the brachial artery, systolic and diastolic blood flow velocities were measured by Doppler. Results:  The SDFV ratio was positively related to endothelium-independent vasodilatation, while inverse relations were found to flow-mediated dilation, common carotid artery distensibility and the stroke volume to pulse pressure ratio. Endothelium-dependent vasodilatation and total peripheral resistance index were not significantly related to the SDFV ratio. The SDFV ratio (P = 0·015) and the blood flow increase (BFI) during hyperaemia (P = 0·020) were both significantly related to TAS after gender adjustment. When adjusted for the Framingham risk score, both the SDFV ratio (P = 0·057) and BFI (P = 0·078) lost somewhat in significance. Conclusion:  The SDFV ratio was related to established markers of both vasodilation and arterial compliance, and to global atherosclerosis. Future larger studies have to evaluate whether the SDFV ratio is related to global atherosclerosis independently of traditional risk factors.
Susann J Järhult; Tomas Hansen; Håkan Ahlström; Lars Johansson; Johan Sundström; Lars Lind
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Publication Detail:
Type:  Journal Article     Date:  2012-01-24
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  32     ISSN:  1475-097X     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Clinical Physiology and Functional Imaging © 2012 Scandinavian Society of Clinical Physiology and Nuclear Medicine.
Department of Medical Sciences Uppsala University Hospital Department of Radiology, Uppsala University Hospital, Uppsala Astra Zeneca, R&D, Mölndal, Sweden.
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