Document Detail


Brachial artery diameter and vasodilator response to nitroglycerine, but not flow-mediated dilatation, are associated with the presence and quantity of coronary artery calcium in asymptomatic adults.
MedLine Citation:
PMID:  16987102     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we investigated whether measures of brachial artery reactivity were associated with the presence and extent of subclinical coronary atherosclerosis in asymptomatic adults. Electron beam computed tomography was employed to assess the presence and quantity of CAC (coronary artery calcium) in 441 participants (mean age, 61 years; 49% men) without prior history of CHD (coronary heart disease) or stroke, and CAC score was calculated using the method described by Agatston and co-workers [(1990) J. Am. Coll. Cardiol. 15, 827-832] High-resolution ultrasound was employed to measure BAD (brachial artery diameter), FMD (flow-mediated dilatation) and NMD (nitroglycerine-mediated dilatation). CAC score and FMD were log-transformed after adding 1 to reduce skewness. Multivariable logistic and linear regression models based on generalized estimating equations were used to assess whether BAD, FMD and NMD were each independently associated with the presence and quantity of CAC after adjustment for CHD risk factors and use of statin and hypertension medication. CAC was detectable in 64% of participants. After adjustment for age and sex, FMD was not correlated (r=-0.06; P=0.27), BAD was positively correlated (r=0.16; P=0.004) and NMD was inversely correlated in a borderline significant manner (r=-0.10; P=0.084) with log(CAC+1). In multivariable logistic regression analyses, FMD was not associated, whereas higher BAD (P=0.021) and lower NMD (P=0.030) were independently associated with the presence of CAC. In multivariable linear regression analyses, higher BAD (P=0.004) and lower NMD (P=0.016), but not FMD, were independently associated with log(CAC+1). We conclude that greater diameter of the brachial artery and lower vasodilator response to nitroglycerine, but not FMD, are associated with subclinical coronary atherosclerosis.
Authors:
Iftikhar J Kullo; A Rauoof Malik; Lawrence F Bielak; Patrick F Sheedy; Stephen T Turner; Patricia A Peyser
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  112     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-03     Completed Date:  2007-02-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  175-82     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN 55905, USA. kullo.iftikhar@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Brachial Artery / pathology,  physiopathology*,  ultrasonography
Calcinosis / metabolism,  physiopathology
Calcium / analysis*
Coronary Artery Disease / diagnosis,  metabolism,  physiopathology*
Coronary Vessels / chemistry*
Female
Humans
Male
Middle Aged
Nitroglycerin / diagnostic use
Risk Factors
Tomography, X-Ray Computed
Vasodilation* / drug effects
Vasodilator Agents / diagnostic use
Grant Support
ID/Acronym/Agency:
K-23, RR17720/RR/NCRR NIH HHS; M01 RR00585/RR/NCRR NIH HHS; R01 HL46292/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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