| Brachial-ankle vs carotid-femoral pulse wave velocity as a determinant of cardiovascular structure and function. | |
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MedLine Citation:
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PMID: 17597797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carotid-femoral pulse wave velocity (cf-PWV) is a validated marker of arterial stiffening over the central arteries. Brachial-ankle pulse wave velocity (ba-PWV) integrates the mechanical properties from both the central and peripheral arteries and may be more representative than cf-PWV as arterial load for left ventricle (LV). We compared ba-PWV with cf-PWV for the association of cardiovascular structure and function in 320 subjects with various degrees of abnormality in cardiac structure and function. ba-PWV (by oscillometric technique) and cf-PWV (by tonometric technique) were measured simultaneously, and were highly correlated (r=0.79, P<0.001). Both ba-PWV and cf-PWV were significantly correlated with LV mass, but the correlation was better with ba-PWV (r=0.29 vs r=0.22, P=0.0219). While ba-PWV and cf-PWV were similarly significantly correlated with LV end-systolic elastance and mitral E/A ratio, ba-PWV had better correlation with isovolumic relaxation constant (r=0.34 vs r=0.27, P=0.0202) than cf-PWV. In addition, the correlation was also significantly stronger with ba-PWV than with cf-PWV for other indices of arterial stiffness, including carotid incremental modulus (r=0.59 vs 0.50, P=0.0013), effective arterial elastance (r=0.41 vs r=0.33, P=0.0081) and carotid augmentation index (r=0.38 vs r=0.32, P=0.0368). In conclusion, ba-PWV correlates better with LV mass and diastolic function and other indices of arterial function than cf-PWV, probably because ba-PWV encompasses a greater territory of arterial tree than cf-PWV. |
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Authors:
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W-C Yu; S-Y Chuang; Y-P Lin; C-H Chen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-28 |
Journal Detail:
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Title: Journal of human hypertension Volume: 22 ISSN: 0950-9240 ISO Abbreviation: J Hum Hypertens Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-13 Completed Date: 2008-03-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811625 Medline TA: J Hum Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 24-31 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arteries / physiopathology Blood Flow Velocity* Brachial Artery Cardiovascular Abnormalities / diagnosis*, physiopathology Carotid Arteries Diagnosis, Computer-Assisted* Echocardiography Elasticity Female Femoral Artery Heart / physiopathology Humans Male Middle Aged Reproducibility of Results |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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