Document Detail

Brachial-ankle pulse wave velocity as a marker of subclinical organ damage in middle-aged patients with hypertension.
MedLine Citation:
PMID:  18522791     Owner:  NLM     Status:  In-Process    
OBJECTIVE: This study was conducted to clarify whether the brachial-ankle pulse wave velocity (baPWV) might serve as a marker of target organ damage in middle-aged hypertensive subjects.
METHODS AND RESULTS: Multivariate linear regression analysis demonstrated that while the baPWV showed a significant relationship to the intima-media thickness of the carotid artery (IMT), no such relationship was observed between the baPWV and the left ventricular mass index as assessed by echocardiography or the estimated glomerular filtration rate in either the 162 hypertensive patients who had never previously received antihypertensive medication or the 269 hypertensive patients who were under antihypertensive medication for at least 1 year. Receiver-operator characteristic (ROC) curve analysis suggested that a baPWV=18m/s was the best cutoff value to identify increased IMT in hypertensive patients who had never previously received antihypertensive medication (area under curve=0.77). Binary logistic regression analysis demonstrated that the odds ratio (OR) of a baPWV of ≥18m/s for identifying increased IMT {OR=7.38 (1.94-28.05)} was significant, even after adjustments. In hypertensive patients who had been under antihypertensive medication for at least 1 year, however, the area under the curve and OR were only modest.
CONCLUSION: The baPWV may be a marker of carotid atherosclerosis, rather than of left ventricular hypertrophy or renal insufficiency, especially in middle-aged hypertensive subjects (subjects in their 30s to 60s), not only in those who have never previously received antihypertensive medication, but also in those who are under antihypertensive medication.
Chisa Matsumoto; Hirofumi Tomiyama; Jiko Yamada; Masanobu Yoshida; Kazuki Shiina; Akira Yamashina
Publication Detail:
Type:  Journal Article     Date:  2008-04-21
Journal Detail:
Title:  Journal of cardiology     Volume:  51     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  163-70     Citation Subset:  IM    
Second Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
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