| Brachial-ankle pulse wave velocity is an independent risk factor for microalbuminuria in patients with essential hypertension--a Japanese trial on the prognostic implication of pulse wave velocity (J-TOPP). | |
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MedLine Citation:
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PMID: 17044664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Brachial-ankle pulse wave velocity is a new measure of arterial stiffness. The clinical significance of brachial-ankle pulse wave velocity as a measure of early vascular damage remains unclear. We examined the hypothesis that higher brachial-ankle pulse wave velocity is associated with a much greater risk of albuminuria by employing a cohort of 718 never-treated hypertensive patients registered in a prospective study. The 718 patients consisted of 500 patients with normoalbuminuria (69.6%), 191 patients with microalbuminuria (26.6%) and 27 patients with macroalbuminuria (3.8%). The prevalence of microalbuminuria increased with a graded increase in brachial-ankle pulse wave velocity (17.6, 22.8, 28.2 and 39.6%, p < 0.0001). The prevalence of macroalbuminuria remained constant until the third grade group of the brachial-ankle pulse wave velocity but increased significantly in the highest grade group compared with the lower grade groups (2.3, 3.2, 2.3, 9.9%, p < 0.0001). Age, systolic and diastolic blood pressure, pulse pressure, heart rate, and fasting glucose concentration were also significantly increased with an increase in brachial-ankle pulse wave velocity (p < 0.0001 for all). Multiple logistic regression analysis has shown that systolic blood-pressure, fasting blood glucose, and brachial-ankle pulse wave velocity are significant risk factors for microalbuminuria. After adjusting for other risk factors, the odds ratio for an increase of 200 cm/s in brachial-ankle pulse wave velocity was 1.192 (95% confidence interval: 1.022-1.365; p < 0.05). These data suggest that brachial-ankle pulse wave velocity is an independent risk factor for microalbuminuria and could be used as a marker for early vascular damage in never-treated hypertensive patients. |
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Authors:
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Masanori Munakata; Tohru Nunokawa; Kaoru Yoshinaga; Takayoshi Toyota; |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 29 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-10-18 Completed Date: 2006-11-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
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Languages: eng Pagination: 515-21 Citation Subset: IM |
Affiliation:
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Preventive Medical Center, Tohoku Rosai Hospital, Sendai, Japan. munakata@tohokuh.rofuku.go.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Albuminuria / epidemiology, etiology* Ankle / blood supply* Blood Glucose / metabolism Brachial Artery / physiology* Cohort Studies Cross-Sectional Studies Female Humans Hypertension / complications* Japan / epidemiology Logistic Models Male Middle Aged Prognosis Prospective Studies Regional Blood Flow / physiology Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
| Comments/Corrections | |
Comment In:
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Hypertens Res. 2006 Jul;29(7):469-70
[PMID:
17044657
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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