Document Detail


Brachial-ankle pulse wave velocity: an index of central arterial stiffness?
MedLine Citation:
PMID:  15729378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brachial-ankle pulse wave velocity (baPWV) is a promising technique to assess arterial stiffness conveniently. However, it is not known whether baPWV is associated with well-established indices of central arterial stiffness. We determined the relation of baPWV with aortic (carotid-femoral) PWV, leg (femoral-ankle) PWV, and carotid augmentation index (AI) by using both cross-sectional and interventional approaches. First, we studied 409 healthy adults aged 18-76 years. baPWV correlated significantly with aortic PWV (r = 0.76), leg PWV (r = 0.76), and carotid AI (r = 0.52). A stepwise regression analysis revealed that aortic PWV was the primary independent correlate of baPWV, explaining 58% of the total variance in baPWV. Additional 23% of the variance was explained by leg PWV. Second, 13 sedentary healthy men were studied before and after a 16-week moderate aerobic exercise intervention (brisk walking to jogging; 30-45 min/day; 4-5 days/week). Reductions in aortic PWV observed with the exercise intervention were significantly and positively associated with the corresponding changes in baPWV (r = 0.74). A stepwise regression analysis revealed that changes in aortic PWV were the only independent correlate of changes in baPWV (beta = 0.74), explaining 55% of the total variance. These results suggest that baPWV may provide qualitatively similar information to those derived from central arterial stiffness although some portions of baPWV may be determined by peripheral arterial stiffness.
Authors:
J Sugawara; K Hayashi; T Yokoi; M Y Cortez-Cooper; A E DeVan; M A Anton; H Tanaka
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of human hypertension     Volume:  19     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-19     Completed Date:  2005-08-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  401-6     Citation Subset:  IM    
Affiliation:
Institute for Human Science and Bioengineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan. jun.sugawara@aist.go.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Ankle / blood supply
Arteriosclerosis / etiology,  physiopathology
Blood Flow Velocity / physiology*
Blood Pressure / physiology*
Blood Pressure Determination / methods
Brachial Artery / physiology*
Carotid Artery, Common / physiology
Compliance
Cross-Sectional Studies
Exercise / physiology
Female
Femoral Artery / physiology
Humans
Japan
Male
Middle Aged
Plethysmography
Predictive Value of Tests
Pulse
Reference Values
Rest / physiology
Risk Factors
Supine Position / physiology
Tibial Arteries / physiology*
United States
Grant Support
ID/Acronym/Agency:
AG20966/AG/NIA NIH HHS; HL072729/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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