Document Detail

Bowen's disease of the nail bed and periungual area. A clinicopathologic analysis of seven cases.
MedLine Citation:
PMID:  8304759     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This article describes the clinical and histologic features of seven cases of Bowen's disease (BD) of the nail bed, evaluates the role of human papillomavirus in the bowenoid change, and discusses optimal therapy. OBSERVATION: The patients presented with the clinical features of verruca vulgaris (n = 3), nail dystrophy and onycholysis (n = 2), paronychia (n = 1), and acral melanoma (n = 1). Histologically, the lesions demonstrated acanthosis, hyperkeratosis, and anaplasia, involving the full thickness of the epithelium. In four cases, human papillomavirus type 16 was demonstrated by in situ hybridization. Six lesions were treated by Mohs micrographic surgery, and one case was treated with topical 5% fluorouracil. In two cases, lesions recurred 1 and 2 years following surgery. In the case treated with topical 5% fluorouracil, residual BD was found 6 weeks after therapy. This case was then treated by Mohs surgery. CONCLUSIONS: Bowen's disease of the nail bed and periungual area may present clinically as various inflammatory and neoplastic conditions. An important clinical finding in differentiating BD of the nail bed from verruca is the presence of scaling and onycholysis that are out of proportion to the verrucous changes. Human papillomavirus type 16 may be etiologically related to BD of the nail bed and periungual area. Mohs micrographic surgery is recommended for adequate excision and maximal preservation of normal tissue and function.
P Sau; S L McMarlin; L C Sperling; R Katz
Related Documents :
3814279 - Stabilization of patients prior to interhospital transfer.
9741469 - Thirteen cases of niikawa-kuroki syndrome: report and review with emphasis on medical c...
1227699 - Intraluminal iliac venous calcification.
6662699 - Strongyloidiasis in infancy. case report and review.
2406669 - Histiocytosis x of the vulva: a case report and review of the literature.
17468989 - Clostridium difficile small-bowel enteritis after total proctocolectomy: a rare but fat...
23398009 - Understanding and encouraging feedback-seeking behaviour: a literature review.
3784439 - Cranial sclerosis with striated bone disease (osteopathia striata).
940239 - Carbon monoxide intoxication: a review of 14 patients.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  130     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-03-08     Completed Date:  1994-03-08     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  AIM; IM    
Department of Dermatology, Walter Reed Army Medical Center, Washington, DC.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bowen's Disease / microbiology,  pathology*,  surgery
In Situ Hybridization
Microsurgery / methods
Middle Aged
Nail Diseases / pathology*,  surgery
Papillomaviridae / isolation & purification
Skin Neoplasms / microbiology,  pathology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Profound deficiency in normal circulating T cells in erythrodermic cutaneous T-cell lymphoma.
Next Document:  Transcriptional control and cell type specificity of HPV gene expression.