Document Detail

Bovine spinal muscular atrophy: AFG3L2 is not a positional candidate gene.
MedLine Citation:
PMID:  16130464     Owner:  NLM     Status:  MEDLINE    
Bovine spinal muscular atrophy (BSMA) is a neurodegenerative disorder, which is widespread in Brown Swiss cattle. Main symptoms of the disease are muscular atrophy and recumbency. Affected calves die within few days or weeks. BSMA seems to be inherited as a recessive trait and the disease allele appears to have a common origin. In this study, a pedigree with 30 affected BSMA calves was used to genetically localize the BSMA locus. Linkage analysis was performed between microsatellite markers of seven chromosomes, where the homologous genes of human neurodegenerative disorders are located according to comparative mapping data, and the disease genotype. BSMA was mapped to chromosome 24 confirming the recently published localization (Medugorac et al. 2003). The candidate gene AFG3L2 was physically mapped to chromosome 24q24 using fluorescence in situ hybridization. Due to their different localizations AFG3L2 is not a positional candidate for BSMA. An informative marker localized on the telomeric side of the BSMA locus would be beneficial for marker-assisted selection as well as searching for the causative gene. However, finding a marker distal to BSMA locus is difficult because of its position at the end of the chromosome.
H Joerg; J Muntwyler; M L Glowatzki-Mullis; E Ahrens; M Asai-Coakwell; G Stranzinger
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of animal breeding and genetics = Zeitschrift für Tierzüchtung und Züchtungsbiologie     Volume:  122 Suppl 1     ISSN:  0931-2668     ISO Abbreviation:  J. Anim. Breed. Genet.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-08-31     Completed Date:  2005-12-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100955807     Medline TA:  J Anim Breed Genet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  103-7     Citation Subset:  IM    
Department of Animal Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland.
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MeSH Terms
Adenosine Triphosphatases / genetics*
Cattle Diseases / genetics*
Chromosome Mapping / veterinary
DNA Primers
Genetic Testing
In Situ Hybridization, Fluorescence / veterinary
Microsatellite Repeats / genetics
Muscular Atrophy, Spinal / genetics,  veterinary*
Sequence Analysis, DNA / veterinary
Reg. No./Substance:
0/DNA Primers; EC 3.6.1.-/Adenosine Triphosphatases

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