| Bovine polymerized hemoglobin increases cardiac oxygen consumption and alters myocardial substrate metabolism in conscious dogs: role of nitric oxide. | |
| | |
MedLine Citation:
|
PMID: 10630737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated the effect of bovine polymerized hemoglobin-based oxygen carrying (HBOC) solution on myocardial oxygen consumption (MVO2) and substrate use. At 15 min after the end of HBOC infusion (20% blood volume, i.v.) in nine permanently instrumented conscious dogs, mean arterial pressure and coronary blood flow were both increased by 41+/-5% and 93+/-20% (p<0.01) without affecting late diastolic coronary resistance and left ventricular dP/dtmax. Administration of HBOC did not affect arterial PO2 or O2 content, but significantly decreased coronary sinus PO2 and O2 content by 21+/-3% and 36+/-3%, respectively. MVO2 was increased from 7.2+/-0.8 to 15+/-1.8 ml O2/min (p<0.01). Despite an increase in triple product from 44+/-2 to 56+/-3 (p<0.01) 15 min after HBOC, the ratio of MVO2 and triple product was markedly elevated by 62+/-19%. Myocardial free fatty acid consumption was decreased from 14+/-1 to 4.5+/-2.2 microEq/min, whereas consumption of lactate increased from 19+/-6 to 69+/-10 micromol/ min and that of glucose increased from 1.0+/-0.5 to 10+/-3 mg/min (all p values, <0.05). These metabolic changes were not observed in dogs that received angiotensin II at a dose used (20-40 ng/kg/min, i.v.) to match those hemodynamic effects of HBOC. These results suggest that administration of HBOC increases coronary blood flow and MVO2 and shifts cardiac metabolism from using free fatty acid to using lactate and glucose in conscious dogs at rest. These metabolic changes are independent of the HBOC-induced change in hemodynamics. |
| | |
Authors:
|
K E Loke; P R Forfia; F A Recchia; X Xu; J C Osorio; M Ochoa; M Gawryl; T H Hintze |
Related Documents
:
|
961587 - Propranolol in experimental myocardial ischemia: dissociation of effects on contraction... 518767 - Effect of multiple arterial haemorrhage on the coronary circulation. 2360667 - Coronary sinus pressure has a direct effect on gradient for coronary perfusion. 6499147 - Dynamic mechanisms in human coronary stenosis. 2771967 - Regional hemodynamic responses to nicotine in conscious and anesthetized dogs: comparat... 20410917 - Swedish hypertension open care retrospective study in men and women (show). |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 35 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2000 Jan |
Date Detail:
|
Created Date: 2000-02-10 Completed Date: 2000-02-10 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 84-92 Citation Subset: IM |
Affiliation:
|
Department of Physiology, New York Medical College, Valhalla 10595, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II
/
pharmacology Animals Blood Gas Analysis Cattle Dogs Female Heart / drug effects* Hemodynamics / drug effects Hemoglobins / pharmacology* Myocardium / metabolism* Nitric Oxide / physiology* Oxygen Consumption / drug effects* Regional Blood Flow / drug effects, physiology Vasoconstrictor Agents / pharmacology Ventricular Function, Left / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
P0-1 HL 43023/HL/NHLBI NIH HHS; R0-1 HL 50142/HL/NHLBI NIH HHS; R0-1 HL 53053/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins; 0/Vasoconstrictor Agents; 10102-43-9/Nitric Oxide; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparative effects of bisoprolol and nitrendipine on exercise capacity in hypertensive patients wit...
Next Document: The hemodynamic effects of adenosine infusion after experimental right heart infarct in young swine.