| Bovine herpesvirus 1 gIV-expressing cells resist virus penetration. | |
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MedLine Citation:
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PMID: 8113725 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interaction of bovine herpesvirus 1 (BHV-1) with the BHV-1 glycoprotein IV (gIV)-expressing cell line D1-1 was examined by radiolabelled virus adsorption assays, in situ autoradiography and electron microscopy. Adsorption of radiolabelled BHV-1 to D1-1 cells was similar to that observed in control cell lines but in situ radiography revealed that virus moved to the nucleus of control but not the gIV-expressing cells. Electron microscopy studies showed that BHV-1 attached to the cell membranes of D1-1 and control cells at 4 degrees C but penetration of virus was observed only in control cells when the temperature was shifted to 37 degrees C. These results provide further evidence that cellular expression of gIV does not prevent viral adsorption, but does prevent the entrance of the virus into the cell. |
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Authors:
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C C Chase; G J Letchworth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of general virology Volume: 75 ( Pt 1) ISSN: 0022-1317 ISO Abbreviation: J. Gen. Virol. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-03-29 Completed Date: 1994-03-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 177-81 Citation Subset: IM |
Affiliation:
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Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison 53706. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography / methods Cattle Cell Line Herpesvirus 1, Bovine / metabolism, pathogenicity, physiology* Microscopy, Electron Viral Interference / physiology* Viral Proteins / biosynthesis, physiology* Virion / physiology |
| Chemical | |
Reg. No./Substance:
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0/Viral Proteins; 0/bovine herpesvirus type-1 glycoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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