Document Detail

Bovine herpesvirus 1 gIV-expressing cells resist virus penetration.
MedLine Citation:
PMID:  8113725     Owner:  NLM     Status:  MEDLINE    
The interaction of bovine herpesvirus 1 (BHV-1) with the BHV-1 glycoprotein IV (gIV)-expressing cell line D1-1 was examined by radiolabelled virus adsorption assays, in situ autoradiography and electron microscopy. Adsorption of radiolabelled BHV-1 to D1-1 cells was similar to that observed in control cell lines but in situ radiography revealed that virus moved to the nucleus of control but not the gIV-expressing cells. Electron microscopy studies showed that BHV-1 attached to the cell membranes of D1-1 and control cells at 4 degrees C but penetration of virus was observed only in control cells when the temperature was shifted to 37 degrees C. These results provide further evidence that cellular expression of gIV does not prevent viral adsorption, but does prevent the entrance of the virus into the cell.
C C Chase; G J Letchworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of general virology     Volume:  75 ( Pt 1)     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-03-29     Completed Date:  1994-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  177-81     Citation Subset:  IM    
Department of Animal Health and Biomedical Sciences, University of Wisconsin-Madison 53706.
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MeSH Terms
Autoradiography / methods
Cell Line
Herpesvirus 1, Bovine / metabolism,  pathogenicity,  physiology*
Microscopy, Electron
Viral Interference / physiology*
Viral Proteins / biosynthesis,  physiology*
Virion / physiology
Reg. No./Substance:
0/Viral Proteins; 0/bovine herpesvirus type-1 glycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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