Document Detail


Bovine ferritin iron bioavailability in man.
MedLine Citation:
PMID:  9088859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bioavailability of ferritin iron was evaluated in human subjects using radiolabelled [55Fe]ferritin isolated from bovine spleen and liver. Preliminary studies with bovine spleen ferritin labelled in vitro demonstrated an inappropriately high absorption compared with ferritin labelled in vivo, and the latter was therefore used in all subsequent absorption studies. In 10 subjects, geometric mean absorption from 5 mg of ferritin iron was 3.8% when taken without and 3.2% when taken with food (P > 0.05). These values were significantly lower than absorption from the same dose of iron given as ferrous sulphate, which averaged 24.1% without and 8.2% with food. When the iron dose was increased 10-fold, absorption of ferritin iron averaged only 0.6-0.7% with or without food as compared with 7.9% without and 2.6% with food when the iron was given as ferrous sulphate. In a further study, mean absorption from bovine spleen ferritin of 4.0% did not differ significantly from the mean of 2.7% observed with bovine liver ferritin. These findings confirm previous studies indicating that ferritin iron is poorly absorbed. Furthermore, its use as a pharmaceutical iron preparation cannot be advocated.
Authors:
B Skikne; D Fonzo; S R Lynch; J D Cook
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  27     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-20     Completed Date:  1997-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  228-33     Citation Subset:  IM    
Affiliation:
Department of Medicine, Kansas University Medical Center, Kansas City 66160-7402, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Biological Availability
Cattle
Female
Ferritins / administration & dosage,  isolation & purification,  pharmacokinetics*
Food
Humans
Intestinal Absorption
Iron / deficiency,  pharmacokinetics*
Iron Radioisotopes
Liver / chemistry
Male
Species Specificity
Spleen / chemistry
Tissue Distribution
Chemical
Reg. No./Substance:
0/Iron Radioisotopes; 7439-89-6/Iron; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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