Document Detail

Bovine colostrum as a biologic in clinical medicine: a review. Part I: biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatment.
MedLine Citation:
PMID:  17474538     Owner:  NLM     Status:  MEDLINE    
Mammals supply their newborn before birth, at birth or shortly after birth with antibodies, immunocytes and humoral constituents. This "borrowed immunity" is a form of passive immunization to protect the newborn against environmental pathogens until it establishes its own pathogen recognition and disposal systems. In cows, goats, horses and some other animal species, most immunoglobulins are obtained from the colostrum, the first milk after birth, via the gut but in humans the majority of immunoglobulins, and those of the IgG-class in particular, are acquired from the mother by placental transport in the weeks prior to parturition. It has long been known that the consumption of bovine colostrum by humans has therapeutic effects e.g. in gastrointestinal infections, but only since the second half of the last century has it been possible to prepare stable, standardized preparations of colostrum. These biologics are administered to patients in combination with standard therapies as so-called balanced supportive diets. Investigations with standardized colostrum preparations in animal models of human disease and estimates of bovine IgG activity in the human GI-tract, described in this review, have provided preclinical data supporting the use of bovine colostrum in human diseases. On the other hand, the number of bovine colostrum products with a sufficiently large and reliable database is limited and the precise nature of the therapeutic targets is still being evaluated.
W G Struff; G Sprotte
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  45     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-03     Completed Date:  2007-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  193-202     Citation Subset:  IM    
Center for Transfusion Medicine, Münster, German Red Cross Blood Transfusion Service West gGmbH, Münster, Germany.
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MeSH Terms
Anti-Infective Agents / pharmacokinetics,  pharmacology*,  standards
Colostrum / chemistry*
Communicable Diseases / drug therapy
Dietary Supplements* / standards
Disease Models, Animal
Immune System / drug effects,  metabolism
Immune System Diseases / drug therapy
Immunoglobulin G / pharmacology
Immunologic Factors / pharmacokinetics,  pharmacology*,  standards
Quality Control
Reg. No./Substance:
0/Anti-Infective Agents; 0/Immunoglobulin G; 0/Immunologic Factors
Comment In:
Int J Clin Pharmacol Ther. 2007 Apr;45(4):191-2   [PMID:  17474537 ]

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