Document Detail


Bovine colostrum as a biologic in clinical medicine: a review. Part I: biotechnological standards, pharmacodynamic and pharmacokinetic characteristics and principles of treatment.
MedLine Citation:
PMID:  17474538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mammals supply their newborn before birth, at birth or shortly after birth with antibodies, immunocytes and humoral constituents. This "borrowed immunity" is a form of passive immunization to protect the newborn against environmental pathogens until it establishes its own pathogen recognition and disposal systems. In cows, goats, horses and some other animal species, most immunoglobulins are obtained from the colostrum, the first milk after birth, via the gut but in humans the majority of immunoglobulins, and those of the IgG-class in particular, are acquired from the mother by placental transport in the weeks prior to parturition. It has long been known that the consumption of bovine colostrum by humans has therapeutic effects e.g. in gastrointestinal infections, but only since the second half of the last century has it been possible to prepare stable, standardized preparations of colostrum. These biologics are administered to patients in combination with standard therapies as so-called balanced supportive diets. Investigations with standardized colostrum preparations in animal models of human disease and estimates of bovine IgG activity in the human GI-tract, described in this review, have provided preclinical data supporting the use of bovine colostrum in human diseases. On the other hand, the number of bovine colostrum products with a sufficiently large and reliable database is limited and the precise nature of the therapeutic targets is still being evaluated.
Authors:
W G Struff; G Sprotte
Related Documents :
16934438 - Lactobacillus paracasei a survives gastrointestinal passage and affects the fecal micro...
19829778 - Diagnosing possible infantile cow's milk protein allergy in rural africa, when history ...
7500198 - The immunologic significance of breast milk.
11960298 - Calcium, phosphorus and magnesium balance: fm 85 fortification of human milk does not m...
10533818 - Cost-effectiveness of a limited-donor blood program for neonatal red cell transfusions.
23072758 - Decreasing perinatal mortality in placental abruption.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  45     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-03     Completed Date:  2007-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  193-202     Citation Subset:  IM    
Affiliation:
Center for Transfusion Medicine, Münster, German Red Cross Blood Transfusion Service West gGmbH, Münster, Germany. w.struff@bsdwest.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / pharmacokinetics,  pharmacology*,  standards
Bacteremia
Cattle
Colostrum / chemistry*
Communicable Diseases / drug therapy
Dietary Supplements* / standards
Disease Models, Animal
Humans
Immune System / drug effects,  metabolism
Immune System Diseases / drug therapy
Immunoglobulin G / pharmacology
Immunologic Factors / pharmacokinetics,  pharmacology*,  standards
Quality Control
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Immunoglobulin G; 0/Immunologic Factors
Comments/Corrections
Comment In:
Int J Clin Pharmacol Ther. 2007 Apr;45(4):191-2   [PMID:  17474537 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Determination of synthetic hormones in animal urine by high-performance liquid chromatography/mass s...
Next Document:  Cost-effectiveness and cost-utility of insulin glargine compared with NPH insulin based on a 10-year...