| Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans. | |
| | |
MedLine Citation:
|
PMID: 17395779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent studies have demonstrated that cell populations intended for therapeutic purposes that are cultured in heterologous animal products can acquire xenoantigens, potentially limiting their utility. In investigations of the immune response to murine embryonic stem cells, we found that a strong antibody response was generated after the second infusion. Both polyclonal and monoclonal antibody responses, derived from immunized mice, were found to be specific for bovine apolipoprotein B-100, which binds to abundant low-density lipoprotein receptors on the cell surface and is internalized. Here we show that in the majority of patients administered 3 different types of cell-based therapies using cells grown in fetal calf serum-containing media, an antibody response to bovine apolipoprotein B-100 develops after the second infusion and is the dominant specificity. The known and potential clinical effects of such antibodies are discussed. |
| | |
Authors:
|
Norihisa Sakamoto; Kazuhide Tsuji; Linda M Muul; Ann M Lawler; Emanuel F Petricoin; Fabio Candotti; Julia A Metcalf; Jorge A Tavel; H Clifford Lane; Walter J Urba; Bernard A Fox; Ajit Varki; Joan K Lunney; Amy S Rosenberg |
Related Documents
:
|
18235539 - Mechanisms of disease: macrophage migration inhibitory factor in sle, ra and atheroscle... 19065049 - Cd36 modulates migration of mouse and human macrophages in response to oxidized ldl and... 11870869 - Borna disease virus-induced accumulation of macrophage migration inhibitory factor in r... 3048809 - Two calcium-binding proteins associated with specific stages of myeloid cell differenti... 1436109 - Rat liver protein linking chemical and immunological detoxification systems. 8131779 - Interactions between bacterial lipopolysaccharides and serum lipoproteins and their pos... 16923169 - Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of ... 19614599 - The innate immune rheostat: influence on lung inflammatory disease and secondary bacter... 21478439 - Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (pfapa) is a disorder of... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Intramural Date: 2007-03-29 |
Journal Detail:
|
Title: Blood Volume: 110 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 2007 Jul |
Date Detail:
|
Created Date: 2007-07-03 Completed Date: 2007-09-13 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
|
Languages: eng Pagination: 501-8 Citation Subset: AIM; IM |
Affiliation:
|
Division of Therapeutic Proteins, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antibody Formation Antigens, Heterophile / immunology Apolipoprotein B-100 / immunology* Blood Banks Cattle Embryonic Stem Cells / immunology Female Fetal Blood / immunology* Humans Mice Mice, Inbred C57BL Mice, Inbred Strains / immunology Mice, Transgenic National Institutes of Health (U.S.) United States Vaccines* |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, Heterophile; 0/Apolipoprotein B-100; 0/Vaccines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early ...
Next Document: Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by pro...