Document Detail

Bovine anaplasmosis: clinical, hematologic, and serologic manifestations in cows given a long-acting oxytetracycline formulation in the prepatent period.
MedLine Citation:
PMID:  7103219     Owner:  NLM     Status:  MEDLINE    
The prophylactic efficacy of a long-acting oxytetracycline formulation was determined in 36 susceptible cows experimentally inoculated with Anaplasma marginale. Each of 10 cows in 3 treatment groups (T2, T3, T4) were given IM injections of 20 mg of oxytetracycline/kg of body weight once, twice, or three times during the prepatent period. The T2 group was treated once at 1 week after experimental inoculation, the T3 group was treated 2 times (at 1 and 2 weeks) after exposure, and the T4 group was treated 3 times (at 1, 2, and 3 weeks) after exposure. Six cows comprising group T1 served as nonmedicated controls. Treatment of cattle in the prepatent period with the long-acting oxytetracycline formulation produced significantly fewer clinical anaplasmosis cases. This reduction in frequency was proportional to the number of weekly treatments given. In cattle which developed clinical disease, only 1 IM injection of 20 mg of oxytetracycline/kg was necessary to induce recovery. The prepatent period in the treated cattle was extended approximately 30 days beyond the prepatent period of the control cattle after their final treatment. Humoral rapid card agglutinating and complement fixing antibodies regularly were present in the cows 10 days after they were inoculated; however, neither the presence of antibody nor that of the antibiotic was sufficient to prevent establishment of the carrier state in the principals.
S D Lincoln; W P Eckblad; R A Magonigle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  43     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1360-2     Citation Subset:  IM    
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MeSH Terms
Anaplasmosis / drug therapy*,  immunology
Antibody Formation / drug effects
Cattle Diseases / drug therapy*,  immunology
Delayed-Action Preparations
Immunity, Cellular / drug effects
Oxytetracycline / administration & dosage*,  pharmacology,  therapeutic use
Pregnancy Complications, Infectious / drug therapy,  immunology,  veterinary*
Reg. No./Substance:
0/Delayed-Action Preparations; 79-57-2/Oxytetracycline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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