Document Detail

Bound malondialdehyde in foods: bioavailability of N,N'-di-(4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde)lysine.
MedLine Citation:
PMID:  14705915     Owner:  NLM     Status:  MEDLINE    
Reactions between lipid peroxidation products and proteins in foods have detrimental nutritional effects, most importantly, losses of essential amino acids. One of the major products of the reaction of malondialdehyde and alkanals with amino groups are 4-substituted 1,4-dihydropyridine-3,5-dicarbaldehyde derivatives. The product of the reaction of lysine with malondialdehyde and acetaldehyde, N,N'-di-(4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde)lysine (MDDL), has been synthesized and used for in vitro and in vivo bioavailability studies. Release of free lysine did not occur in incubations of MDDL with tissue homogenates. After oral administration of radioactively labeled MDDL, radioactivity was only recovered in feces. Radioactivity was not incorporated into hepatic microsomes after intraperitoneal administration, which would have indicated release of available lysine. These results show that MDDL is a form of unavailable lysine, because it is not metabolized to free lysine and cannot be absorbed from the gut. Thus, formation of this derivative in foods would result in loss of available lysine.
Julio Girón-Calle; Manuel Alaiz; Francisco Millán; Valentina Ruiz-Gutierrez; Eduardo Vioque
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  51     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2004-01-06     Completed Date:  2005-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4799-803     Citation Subset:  IM    
Instituto de la Grasa (Consejo Superior de Investigaciones Científicas), Avenida Padre García Tejero, 4, 41012 Sevilla, Spain.
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MeSH Terms
Aldehydes / chemistry,  pharmacokinetics*
Carbon Radioisotopes
Food Analysis*
Intestinal Mucosa / enzymology
Kidney / enzymology
Liver / enzymology
Lysine / analogs & derivatives*,  chemistry*,  pharmacokinetics*
Malondialdehyde / analysis,  chemistry*
Microsomes, Liver / chemistry,  metabolism
Pyridines / chemistry,  pharmacokinetics*
Rats, Wistar
Reg. No./Substance:
0/Aldehydes; 0/Carbon Radioisotopes; 0/N,N'-di-(4-methyl-1,4-dihydropyridine-3,5-dicarbaldehyde)lysine; 0/Pyridines; 10028-17-8/Tritium; 542-78-9/Malondialdehyde; 56-87-1/Lysine

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