Document Detail

Botulism in Alaska, 1947 through 1974. Early detection of cases and investigation of outbreaks as a means of reducing mortality.
MedLine Citation:
PMID:  945998     Owner:  NLM     Status:  MEDLINE    
Since 1947, there have been 21 outbreaks of botulism in Alaska, involving 46 people with 13 deaths (28% fatality). In the last six months of 1974, there were four outbreaks. With one exception to date, type E toxin was involved in all outbreaks for which laboratory confirmation has been obtained, and in all instances, Eskimo and Indian foods were the source. Clinical signs and symptoms of nausea and vomiting, dysphagia, diplopia, dilated pupils, and dry throat occurred with great frequency, forming a diagnostic pentad. We recommend that treatment include close medical supervision, supportive care, and the use of antitoxin, cathartics, and possibly, penicillin. The source of an outbreak must be determined to prevent further cases. Only prompt recognition, therapy and epidemiologic investigation can reduce the death toll from botulism.
M S Eisenberg; T R Bender
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JAMA     Volume:  235     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-02-26     Completed Date:  1976-02-26     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  AIM; IM    
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MeSH Terms
Botulinum Antitoxin / therapeutic use
Botulism / drug therapy,  epidemiology*,  mortality
Cathartics / therapeutic use
Disease Outbreaks / epidemiology*
Feces / microbiology
Food Contamination
Food Microbiology / analysis
Food Preservation
Middle Aged
Penicillins / therapeutic use
Spores, Bacterial / isolation & purification
Reg. No./Substance:
0/Botulinum Antitoxin; 0/Cathartics; 0/Penicillins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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