Document Detail

Botulinum toxin type A in the healing of ulcer following oro-mandibular dyskinesia in a patient in a vegetative state.
MedLine Citation:
PMID:  18382829     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Use of botulinum toxin is expanding as clinical studies demonstrate new potential therapeutic applications. In rehabilitation, botulinum toxin is predominantly used as adjunct therapy for the treatment of spasticity, but it may prove useful for other atypical clinical situations.
CASE HISTORY: A 73-year-old man had a severe sub-arachnoid haemorrhage following the rupture of a giant aneurism of the middle left cerebral artery. Clinically, the patient presented a vegetative state and an oro-mandibular dyskinesia that produced a chronic ulcer on the lower lip. As treatment for this dyskinesia, a total of 320 U botulinum toxin type A were injected into the upper and lower orbicularis oris and masseter muscles.
RESULTS AND DISCUSSION: This treatment allowed for application of topical medication and subsequently, ulcer healing. Botulinum toxin type A may be an important therapeutic aid for clinicians faced with treating persistent pathological conditions caused by dyskinesia.
Domenico Intiso; Mario Basciani; Filomena Di Rienzo; Maurizio Tolfa; Giuseppina Grimaldi; Piero Fiore
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of rehabilitation medicine     Volume:  40     ISSN:  1650-1977     ISO Abbreviation:  J Rehabil Med     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-02     Completed Date:  2008-06-02     Revised Date:  2014-05-30    
Medline Journal Info:
Nlm Unique ID:  101088169     Medline TA:  J Rehabil Med     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  315-6     Citation Subset:  IM    
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MeSH Terms
Botulinum Toxins, Type A / administration & dosage,  therapeutic use*
Chronic Disease
Dyskinesias / complications,  physiopathology
Lip Diseases / drug therapy*,  etiology,  physiopathology
Masticatory Muscles / drug effects,  physiopathology
Neuromuscular Agents / administration & dosage,  therapeutic use*
Oral Ulcer / drug therapy*,  etiology,  physiopathology
Persistent Vegetative State / complications,  physiopathology
Reg. No./Substance:
0/Neuromuscular Agents; EC Toxins, Type A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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