Document Detail


BOTULINUM TOXIN, TYPE A: EFFECTS ON CENTRAL NERVOUS SYSTEM.
MedLine Citation:
PMID:  14245777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study has demonstrated that type A botulinum toxin has a depressant effect on the cortical electrical activity of anesthetized and unanesthetized monkeys. Simultaneous recordings of vital signs indicated a relative lack of change in the electrocardiogram, respiration, blood pressure, and heart rate during this time. The change in the electroencephalogram appeared cyclic in nature and independent of dose or time. All animals exhibited signs of respiratory failure characterized by a gradual interference with neuromuscular transmission at the diaphragm, and subsequently died an anoxic death.
Authors:
E H POLLEY; J A VICK; H P CIUCHTA; D A FISCHETTI; F J MACCHITELLI; N MONTANARELLI
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  147     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1965 Feb 
Date Detail:
Created Date:  1965-04-01     Completed Date:  1996-12-01     Revised Date:  2011-11-30    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1036-7     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Antitoxins*
Blood Pressure*
Clostridium botulinum*
Diaphragm*
Electrocardiography*
Electroencephalography*
Haplorhini*
Heart*
Heart Rate*
Neural Conduction*
Neuromuscular Junction*
Pharmacology*
Research*
Respiration*
Respiratory Insufficiency*
Toxicology*
Toxins, Biological*
Chemical
Reg. No./Substance:
0/Antitoxins; 0/Toxins, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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