Document Detail

Botulinum A toxin treatment for eyelid spasm, spasmodic torticollis and apraxia of eyelid opening.
MedLine Citation:
PMID:  2387698     Owner:  NLM     Status:  MEDLINE    
Botulinum-A toxin (botAtox) was used in the treatment of blepharospasm (BS), idiopathic hemifacial spasm (HFS), idiopathic spasmodic torticollis (ST) and apraxia of eyelid opening (AEO). The injection of 7.5-30 U botAtox per eye spread over 3 or 4 sites in the palpebral part of orbicularis palpebrae (OP) reduced palpebral spasm in 12/13 cases of BS and in 7/8 cases of HFS. The effect lasted for 14.5 weeks on average (range 4-30 weeks). Palpebral ptosis (lasting 1-3 weeks) was the most frequent side effect (16/107 eyes treated) but was not related to dose of botAtox or number of inoculation sites. Injection of 60-160 U botAtox into the sternocleidomastoid, trapezius and splenius capitis muscles reduced ST objectively in 1/4 patients for about 4 weeks. In the other patients the reduction or abolition of the hypertrophy of the previous hyperactive muscles was accompanied by persistence or rearrangement of the dystonia pattern, suggesting a change in the pattern of activity of the neck muscles after botAtox. 5 U botAtox per eye spread over 4 sites in the OP significantly reduced the frequency of the episodes of involuntary eyelid closure in 2 patients with AEO but not BS. The therapeutic effect lasted for 7 months after the first treatment and for 8 months after the second in a 46 year old woman with a 6 month history while the second patient (72 year old parkinsonian) has now completed her 3rd month of treatment.
G Defazio; V Lepore; P Lamberti; P Livrea; E Ferrari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian journal of neurological sciences     Volume:  11     ISSN:  0392-0461     ISO Abbreviation:  Ital J Neurol Sci     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-09-25     Completed Date:  1990-09-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006502     Medline TA:  Ital J Neurol Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  275-80     Citation Subset:  IM    
Instituto di Clinica delle Malattie Nervose e Mentali, Università di Bari.
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MeSH Terms
Apraxias / drug therapy*
Blepharospasm / drug therapy*
Botulinum Toxins / therapeutic use*
Eyelid Diseases / drug therapy*
Facial Muscles
Middle Aged
Spasm / drug therapy*
Torticollis / drug therapy*
Reg. No./Substance:
0/Botulinum Toxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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