Document Detail

Botulinum toxin to improve lower facial symmetry in facial nerve palsy.
MedLine Citation:
PMID:  22975654     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: In long-standing facial palsy, muscles on the normal side overcontract causing difficulty in articulation, eating, drinking, cosmetic embarrassment, and psychological effects as patients lack confidence in public.
METHODS: We injected botulinum toxin A (BTXA) into the normal contralateral smile muscles to weaken them and restore symmetry to both active and passive movements by neutralising these overacting muscles.
RESULTS: A total of 14 patients received BTXA (79% women, median age 47 years, average length of palsy 8 years). They were all difficult cases graded between 2 and 6 (average grade 3 House-Brackmann). All 14 patients reported improved facial symmetry with BTXA (dose altered in some to achieve maximum benefit). Average dose was 30 units, but varied from 10 to 80 units. Average time to peak effect was 6 days; average duration of effect was 11 weeks. Three patients had increased drooling (resolved within a few days).
CONCLUSION: The improvement in symmetry was observed by both patient and examining doctor. Patients commented on increased confidence, being more likely to allow photographs taken of themselves, and families reported improved legibility of speech. Younger patients have more muscle tone than older patients; the effect is more noticeable and the benefit greater for them. BTXA improves symmetry in patients with facial palsy, is simple and acceptable, and provides approximately 4 months of benefit. The site of injection depends on the dynamics of the muscles in each individual patient.
S A Sadiq; S Khwaja; S R Saeed
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-14
Journal Detail:
Title:  Eye (London, England)     Volume:  26     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-05-15     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1431-6     Citation Subset:  IM    
Manchester Royal Eye Hospital, Manchester, UK.
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MeSH Terms
Botulinum Toxins, Type A / therapeutic use*
Facial Asymmetry / drug therapy*,  physiopathology
Facial Expression*
Facial Muscles / drug effects*,  physiopathology
Facial Paralysis / drug therapy*,  physiopathology
Injections, Intramuscular
Middle Aged
Neuromuscular Agents / therapeutic use*
Retrospective Studies
Young Adult
Reg. No./Substance:
0/Neuromuscular Agents; EC Toxins, Type A; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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