| Botulinum toxin therapy in the ovalbumin-sensitized rat. | |
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MedLine Citation:
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PMID: 17713354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to determine whether intranasal administration of botulinum toxin type A (BTX-A) could relieve the typical symptoms of allergic rhinitis (AR) and alter substance P (SP)- and vasoactive intestinal peptide (VIP)-immunoreactive (IR) expression in nasal mucosa of AR animals sensitized with ovalbumin (OVA). METHODS: AR was induced by intraperitoneal injection of OVA followed by its repeated intranasal instillation in female Wistar rats. Some AR animals were intranasally treated with a cotton strip containing BTX-A (10 U per nostril) for 1 h. After BTX-A treatment, OVA was repeatedly instilled in AR and AR + BTX-A groups every 2 days for 10 days. Subsequently, nasal symptoms were evaluated, and nasal secretions collected. Finally, the nasal mucosae of all animals were prepared for histological and immunohistochemical assessment. RESULTS: BTX-A administration alleviated typical AR symptoms including rhinorrhea, nasal itching and sneezing, and subsequent intranasal repeated challenge with OVA did not trigger AR symptoms. After BTX-A treatment, inflammatory histological characteristics within the nasal mucosa of AR animals were absent, but atrophy of serous glands was observed. BTX-A decreased dense SP-IR and VIP-IR cells and fibers within and beneath the epithelium, around blood vessels and close to serous glands in AR animals. CONCLUSION: Local BTX-A treatment is an effective method to reduce AR symptoms. BTX-A decreased the excessive SP-IR and VIP-IR expression induced by OVA. Therefore, BTX-A may affect the nasal mucosa via the suppression of neuropeptides, playing a major role in autonomous mucosal innervation in the pathophysiology of AR. |
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Authors:
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Wei-Dong Wen; Fang Yuan; Jian-Lin Wang; Yi-Ping Hou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-21 |
Journal Detail:
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Title: Neuroimmunomodulation Volume: 14 ISSN: 1021-7401 ISO Abbreviation: Neuroimmunomodulation Publication Date: 2007 |
Date Detail:
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Created Date: 2007-09-20 Completed Date: 2007-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422763 Medline TA: Neuroimmunomodulation Country: Switzerland |
Other Details:
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Languages: eng Pagination: 78-83 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2007 S. Karger AG, Basel. |
Affiliation:
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School of Life Science, Lanzhou University, Lanzhou, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Intranasal Allergens / immunology Animals Botulinum Toxin Type A / administration & dosage* Female Immunohistochemistry Nasal Mucosa / drug effects* Ovalbumin / immunology Rats Rats, Wistar Rhinitis, Allergic, Seasonal / chemically induced, drug therapy* Substance P / drug effects Vasoactive Intestinal Peptide / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Botulinum Toxin Type A; 33507-63-0/Substance P; 37221-79-7/Vasoactive Intestinal Peptide; 9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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