| Botulinum toxin A prolongs functional durability of voice prostheses in laryngectomees with pharyngoesophageal spasm. | |
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MedLine Citation:
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PMID: 19880024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Laryngectomized patients with pharyngoesophageal spasm frequently have poor voice quality and dysphagia. Local botulinum toxin A (BTA) injection can relieve muscular hypertonicity and improve symptoms. This procedure should also prolong the functional life span of the tracheoesophageal voice prosthesis. MATERIALS AND METHODS: This study evaluates 33 BTA treatments in 11 laryngectomees. All patients were having poor voice quality; 6 patients had additional dysphagia. In 10 patients, the BTA injection has been carried out during rigid pharyngoscopy under general anesthesia. One patient was treated in local anesthesia. RESULTS: A subjective improvement of voice quality was reported in 94%. This lasted on average for 20 weeks. The swallowing function improved moderately. For the first time, the functional life span of voice prostheses was examined. After treatment of pharyngoesophageal spasm, their durability was almost tripled. The BTA therapy has a significant effect. CONCLUSIONS: The BTA treatment improves voice quality and prolongs functional durability of voice prostheses in laryngectomees with pharyngoesophageal spasm. The success of treatment is of limited duration but can be repeated in the long-term. |
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Authors:
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Eike Krause; John-Martin Hempel; Robert G??rkov |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-09 |
Journal Detail:
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Title: American journal of otolaryngology Volume: 30 ISSN: 1532-818X ISO Abbreviation: Am J Otolaryngol Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2010-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000029 Medline TA: Am J Otolaryngol Country: United States |
Other Details:
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Languages: eng Pagination: 371-5 Citation Subset: IM |
Affiliation:
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Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Ludwig-Maximilians-University Munich, Munich, Germany. eike.krause@med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Botulinum Toxin Type A / administration & dosage, therapeutic use* Deglutition Disorders / drug therapy, etiology Female Humans Injections, Intramuscular Laryngeal Neoplasms / complications, surgery Laryngectomy / adverse effects* Larynx, Artificial* Male Middle Aged Muscle Hypertonia / drug therapy, etiology Muscle Spasticity / drug therapy*, etiology Neuromuscular Agents / administration & dosage, therapeutic use* Pharyngeal Muscles* / drug effects Quality of Life Retrospective Studies Speech, Esophageal Treatment Outcome Voice Disorders / drug therapy, etiology |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxin Type A; 0/Neuromuscular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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