Document Detail

Botulinum toxin for lower limb spasticity in children with cerebral palsy: a single-blinded trial comparing dilution techniques.
MedLine Citation:
PMID:  15385785     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the effect of equivalent doses of botulinum toxin type A given in high-volume or low-volume injections on lower limb spasticity in children with cerebral palsy. DESIGN: A total of 17 subjects whose modified Ashworth scale scores in the calf flexors bilaterally ranged from 2 to 3 were enrolled. The right gastrocnemius was injected with botulinum toxin type A using a high-volume preparation (100 IU/4 ml), and the left gastrocnemius was injected with a low-volume preparation (100 IU/1 ml). The amplitude and area of the compound muscle action potential for both medial gastrocnemius muscles, the dynamic muscle range, static muscle range, modified Ashworth scale for both ankles, and the Gross Motor Functional Classification System were assessed before and after treatment. RESULTS: Spasticity was reduced in both legs. There was no significant difference in the changes in the amplitude and area of compound muscle action potential (P = 0.74 and 0.30, respectively), dynamic muscle range (P = 0.7), static muscle range (P = 0.65), and modified Ashworth scale (P = 1) in the right vs. left legs after botulinum toxin type A injection. The high-volume preparation did not cause more pain. CONCLUSIONS: A higher volume preparation with a 4-fold dilution of botulinum toxin type A does not yield better results than a low-volume preparation.
Li-Rong Lee; Yao-Chia Chuang; Baii-Jia Yang; Min-Jung Hsu; Ying-Hung Liu
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  83     ISSN:  0894-9115     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-23     Completed Date:  2004-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  766-73     Citation Subset:  AIM; IM    
Department of Physical Medicine and Rehabilitation, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China.
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MeSH Terms
Action Potentials / drug effects
Botulinum Toxin Type A / administration & dosage*
Cerebral Palsy / drug therapy*
Child, Preschool
Dose-Response Relationship, Drug
Drug Compounding / methods
Injections, Intramuscular
Muscle Spasticity / drug therapy
Single-Blind Method
Treatment Outcome
Reg. No./Substance:
0/Botulinum Toxin Type A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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