Document Detail

Botulinum toxin in the treatment of post-radiosurgical neck contracture in head and neck cancer: a novel approach.
MedLine Citation:
PMID:  22104582     Owner:  NLM     Status:  MEDLINE    
PATIENTS AND METHODS: A single-center pilot study was run from January 2007 to July 2008, respecting the Declaration of Helsinki. All patients in complete remission from head-and-neck cancer with post-radiosurgical neck contracture impairing neck motion were included. Pain and functional impairment were assessed on a neck-function disability scale before and 1 month after botulinum toxin injection. Efficacy duration was measured. Complications at the injection site or related to drug diffusion were investigated.
RESULTS: Nine consecutive patients (six male, three female; mean age, 61 years [range, 52-73 years]) were included. In six patients, the sternocleidomastoid muscle was injected and the muscular pedicle of a pectoralis major flap in three. Mean cervical disability score fell significantly from 33 to 23 (P=0.01). There were no complications. Efficacy was seen at a mean 6 days, and analgesia and muscle relaxation lasted for a mean 19 days.
CONCLUSION: In post-radiosurgical neck contracture, botulinum toxin injection is a simple and easy procedure able to improve neck motion and reduce neck pain in head-and-neck cancer patients. A phase-II prospective study to determine injection sites and dosage should help bear out these preliminary findings.
C-A Bach; I Wagner; X Lachiver; B Baujat; F Chabolle
Publication Detail:
Type:  Journal Article     Date:  2011-11-21
Journal Detail:
Title:  European annals of otorhinolaryngology, head and neck diseases     Volume:  129     ISSN:  1879-730X     ISO Abbreviation:  Eur Ann Otorhinolaryngol Head Neck Dis     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-03-12     Completed Date:  2012-07-30     Revised Date:  2014-10-30    
Medline Journal Info:
Nlm Unique ID:  101531465     Medline TA:  Eur Ann Otorhinolaryngol Head Neck Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
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MeSH Terms
Botulinum Toxins, Type A / therapeutic use*
Contracture / drug therapy*,  etiology*
Head and Neck Neoplasms / radiotherapy*,  surgery*
Middle Aged
Neuromuscular Agents / therapeutic use*
Pilot Projects
Postoperative Complications / drug therapy*
Radiation Injuries / drug therapy*
Reg. No./Substance:
0/Neuromuscular Agents; EC Toxins, Type A

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