| Botulinum toxin in the treatment of diffuse esophageal spasm. | |
| | |
MedLine Citation:
|
PMID: 20459446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Diffuse esophageal spasm is a primary esophageal motility disorder. The prevalence is 3-10% in patients with dysphagia and treatment options are limited. This review summarizes the treatment of diffuse esophageal spasm, including pharmacotherapy, endoscopic treatment, and surgical treatment with a special focus on botulinum toxin injection. A PubMed search was performed to identify the literature using the search items diffuse esophageal spasm and treatment. Pharmacotherapy with smooth muscle relaxants, proton pump inhibitors, and antidepressants was suggested from small case series and uncontrolled clinical trials. Endoscopic injection of botulinum toxin is a well-studied treatment option and results in good symptomatic benefit in patients with diffuse esophageal spasm. Surgical treatment was reported in patients with very severe symptoms refractory to pharmacologic treatment. This article summarizes the present knowledge on the treatment of diffuse esophageal spasm with a special emphasis on botulinum toxin injection. Endoscopic injection of botulinum toxin is presently the best studied treatment option but many questions remain unanswered. |
| | |
Authors:
|
M Bashashati; C Andrews; S Ghosh; M Storr |
Related Documents
:
|
19389096 - Botulinum toxin: a treatment for compensatory hyperhidrosis in the trunk. 20112186 - Effectiveness of botulinum-a toxin for the treatment of refractory overactive bladder i... 10647656 - Logistic regression and survival analysis of 450 impotent patients treated with injecti... 16012436 - Treatment of recalcitrant intermetatarsal neuroma with 4% sclerosing alcohol injection:... 20825256 - Treatment of hypertrophic scars and keloids with a fractional co2 laser: a personal exp... 22070796 - Clinical efficacy of aniracetam, either as monotherapy or combined with cholinesterase ... |
Publication Detail:
|
Type: Journal Article; Review Date: 2010-05-04 |
Journal Detail:
|
Title: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E Volume: 23 ISSN: 1442-2050 ISO Abbreviation: Dis. Esophagus Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-10-05 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8809160 Medline TA: Dis Esophagus Country: Australia |
Other Details:
|
Languages: eng Pagination: 554-60 Citation Subset: IM |
Copyright Information:
|
© 2010 Copyright the Authors. Journal compilation © 2010, Wiley Periodicals, Inc. and the International Society for Diseases of the Esophagus. |
Affiliation:
|
Division of Gastroenterology, Department of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Dyskinesia Agents
/
therapeutic use* Botulinum Toxins / therapeutic use* Esophageal Spasm, Diffuse / diagnosis, drug therapy*, physiopathology Esophagoscopy Humans |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Dyskinesia Agents; EC 3.4.24.69/Botulinum Toxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adenocarcinoma occurring at the interposed colon graft for treatment of benign esophageal stricture.
Next Document: Do patients with globus sensation respond to hypnotically assisted relaxation therapy? A case series...