| Botulinum toxin improves dysphagia associated with multiple sclerosis. | |
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MedLine Citation:
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PMID: 20731706 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective: To evaluate the efficacy of botulinum neurotoxin type A (BoNT/A) for severe oro-pharyngeal dysphagia associated with multiple sclerosis (MS). Patients and methods: BoNT/A was injected percutaneously into the hyperactive cricopharyngeal muscle of 14 dysphagic MS patients under electromyographic control. Patients were evaluated by videofluoroscopic and electromyographic examinations and by the Penetration/Aspiration Scale (PAS), at week 1, 4, 12, 16, 18, and 24 after BoNT/A injection. Results: All patients showed a significant improvement in all the swallowing outcome measures. Conclusion: No specific treatment for oro-pharyngeal dysphagia related to MS has been described to date. Our preliminary findings suggest a potential benefit from BoNT/A treatment in MS patients with dysphagia associated with upper esophageal sphincter hyperactivity. |
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Authors:
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D A Restivo; R Marchese-Ragona; F Patti; C Solaro; D Maimone; G Zappalá; A Pavone |
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Publication Detail:
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Type: Journal Article Date: 2010-08-22 |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 18 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 486-90 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s). European Journal of Neurology © 2010 EFNS. |
Affiliation:
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Department of Neurology, "Nuovo Garibaldi" Hospital, Catania ENT Department, University of Padua, Padua Department of Neurological Sciences, Centro Sclerosi Multipla, University of Catania, Catania Department of Neurology, ASL 3 genovese, Genova, Italy. |
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