Document Detail

Botulinum toxin improves dysphagia associated with multiple sclerosis.
MedLine Citation:
PMID:  20731706     Owner:  NLM     Status:  In-Data-Review    
Objective:  To evaluate the efficacy of botulinum neurotoxin type A (BoNT/A) for severe oro-pharyngeal dysphagia associated with multiple sclerosis (MS). Patients and methods:  BoNT/A was injected percutaneously into the hyperactive cricopharyngeal muscle of 14 dysphagic MS patients under electromyographic control. Patients were evaluated by videofluoroscopic and electromyographic examinations and by the Penetration/Aspiration Scale (PAS), at week 1, 4, 12, 16, 18, and 24 after BoNT/A injection. Results:  All patients showed a significant improvement in all the swallowing outcome measures. Conclusion:  No specific treatment for oro-pharyngeal dysphagia related to MS has been described to date. Our preliminary findings suggest a potential benefit from BoNT/A treatment in MS patients with dysphagia associated with upper esophageal sphincter hyperactivity.
D A Restivo; R Marchese-Ragona; F Patti; C Solaro; D Maimone; G Zappalá; A Pavone
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Publication Detail:
Type:  Journal Article     Date:  2010-08-22
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  18     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  486-90     Citation Subset:  IM    
Copyright Information:
© 2010 The Author(s). European Journal of Neurology © 2010 EFNS.
Department of Neurology, "Nuovo Garibaldi" Hospital, Catania ENT Department, University of Padua, Padua Department of Neurological Sciences, Centro Sclerosi Multipla, University of Catania, Catania Department of Neurology, ASL 3 genovese, Genova, Italy.
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