Document Detail

Botulinum toxin and gastrointestinal tract disorders: panacea, placebo, or pathway to the future?
MedLine Citation:
PMID:  21960915     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The history of botulinum toxin is fascinating. First recognized as the cause of botulism nearly 200 years ago, it was originally feared as a deadly poison. Over the last 30 years, however, botulinum toxin has been transformed into a readily available medication used to treat a variety of medical disorders. Interest in the use of botulinum toxin has been particularly strong for patients with spastic smooth muscle disorders of the gastrointestinal tract. Patients with achalasia, diffuse esophageal spasm, gastroparesis, sphincter of Oddi dysfunction, and anal fissures have all been treated with botulinum toxin injections, often with impressive results. However, not all patients respond to botulinum toxin therapy, and large randomized controlled trials are lacking for many conditions commonly treated with botulinum toxin. This paper reviews the history, microbiology, and pharmacology of botulinum toxin, discusses its mechanism of action, and then presents recent evidence from the literature regarding the use of botulinum toxin for the treatment of a variety of gastrointestinal tract disorders.
Brian E Lacy; Kirsten Weiser; Abigail Kennedy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology & hepatology     Volume:  4     ISSN:  1554-7914     ISO Abbreviation:  Gastroenterol Hepatol (N Y)     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2011-09-30     Completed Date:  2011-11-10     Revised Date:  2014-10-16    
Medline Journal Info:
Nlm Unique ID:  101262648     Medline TA:  Gastroenterol Hepatol (N Y)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  283-95     Citation Subset:  -    
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