Document Detail

Botulinum toxin A for drooling in Parkinson's disease: a pilot study to compare submandibular to parotid gland injections.
MedLine Citation:
PMID:  17383926     Owner:  NLM     Status:  MEDLINE    
Drooling is a common and incapacitating problem in Parkinson's disease (PD). Treatment with botulinum neurotoxin (BoNT) into the parotid glands seems beneficial. Injection of the submandibular glands may also be effective since these produce 70% of the daily unstimulated saliva. We randomly allocated patients to BoNT injections into the submandibular glands or the parotid glands. Within-group improvements were significant for the submandibular group, but not for the parotid group. Between-group differences showed a trend towards superiority for the submandibular group. Injecting the submandibular glands instead of the parotid glands seems a promising approach, and larger studies are justified.
Johanna G Kalf; Anne M Smit; Bastiaan R Bloem; Machiel J Zwarts; Wim M Mulleners; Marten Munneke
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-03-26
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  13     ISSN:  1353-8020     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-03-14     Revised Date:  2008-04-15    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  532-4     Citation Subset:  IM    
Department of Allied Health Occupations, Speech Language Therapy, Radboud University Nijmegen Medical Centre, The Netherlands.
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MeSH Terms
Botulinum Toxin Type A / administration & dosage*
Drug Administration Routes
Middle Aged
Neuromuscular Agents / administration & dosage*
Parkinson Disease / drug therapy*,  pathology
Parotid Gland / drug effects*
Pilot Projects
Severity of Illness Index
Statistics, Nonparametric
Submandibular Gland / drug effects*
Reg. No./Substance:
0/Botulinum Toxin Type A; 0/Neuromuscular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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