Document Detail

Botulinum toxin as adjunctive therapy in refractory laryngeal granuloma.
MedLine Citation:
PMID:  17908354     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study evaluated the role of botulinum toxin type A in the treatment of refractory laryngeal granulomas. STUDY DESIGN AND SETTING: Retrospective clinical review at a tertiary care hospital. Seven patients with vocal process granulomas underwent percutaneous injection of botulinum toxin into both vocal folds, performed in an office setting. Total doses ranged from 10 to 25 U, divided between both vocal folds. RESULTS: All patients experienced resolution of their granulomas over two to seven weeks. No patient developed aspiration pneumonia. All patients experienced hoarseness secondary to the injections, but voice quality returned to baseline in all patients as the toxin was degraded. CONCLUSIONS: Botulinum toxin is safe and effective therapy in resolving vocal process granulomas in patients refractory to traditional therapy. The optimal treatment dose remains to be determined. SIGNIFICANCE: Percutaneous botulinum toxin injection is helpful in resolving laryngeal granulomas.
E J Damrose; J F Damrose
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Publication Detail:
Type:  Journal Article     Date:  2007-10-02
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  122     ISSN:  1748-5460     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-17     Completed Date:  2008-09-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  824-8     Citation Subset:  AIM; IM    
Department of Otolaryngology, Head and Neck Surgery, Stanford University Medical Center, Stanford, CA 94305, USA.
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MeSH Terms
Botulinum Toxin Type A / administration & dosage*
Combined Modality Therapy
Drug Administration Schedule
Follow-Up Studies
Granuloma, Laryngeal / drug therapy*,  pathology,  surgery
Middle Aged
Retrospective Studies
Vocal Cords / drug effects,  pathology,  surgery
Voice Quality
Reg. No./Substance:
0/Botulinum Toxin Type A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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