Document Detail

Botulinum toxin type A and B improve quality of life in patients with axillary and palmar hyperhidrosis.
MedLine Citation:
PMID:  23053164     Owner:  NLM     Status:  MEDLINE    
Hyperhidrosis is a common disorder that may have a severe impact on quality of life. The aim of this study was to investigate the clinical effect of two novel botulinum toxins, Xeomin®, a type A botulinum toxin, and Neuro-bloc®, a type B botulinum toxin, in the treatment of axillary and palmar hyperhidrosis. A total of 84 patients, 58 with axillary and 26 with palmar hyperhidrosis, were included in this open study. Axillae were injected with 107 ± 22 U Xeomin® and palms were injected with 213 ± 19 U Xeomin® and 264 ± 60 U Neurobloc® over the thenar eminences to avoid muscle weakness. At follow-up 3 weeks post-treatment, all patients treated for axillary hyperhidrosis reported satisfaction in self-ranking, evaporation decreased > 40%, and Dermatology Life Quality Index (DLQI) score improved from 12.0 to 1.7 (p < 0.05). In the palmar group 95% were satisfied, evaporation decreased > 50% and DLQI score improved from 10.3 to 1.2 (p < 0.05). Only one patient in the palmar group experienced muscle weakness. In conclusion, Xeomin® has an excellent effect on axillary hyperhidrosis and in combination with Neurobloc® on palmar hyperhidrosis. Neurobloc® may be an option for use in the treatment of palmar hyperhidrosis in order to minimize muscular side-effects.
Karolina Rosell; Kristina Hymnelius; Carl Swartling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  93     ISSN:  1651-2057     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-02     Completed Date:  2013-10-17     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  335-9     Citation Subset:  IM    
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MeSH Terms
Botulinum Toxins / administration & dosage,  adverse effects,  therapeutic use*
Botulinum Toxins, Type A / administration & dosage,  adverse effects,  therapeutic use*
Hyperhidrosis / drug therapy*,  physiopathology,  psychology
Muscle Weakness / chemically induced
Patient Satisfaction
Quality of Life*
Sweating / drug effects*
Time Factors
Treatment Outcome
Young Adult
Reg. No./Substance:
0/incobotulinumtoxinA; 0Y70779M1F/rimabotulinumtoxinB; EC Toxins; EC Toxins, Type A

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