Document Detail

Both p140(trk) and p75(NGFR) nerve growth factor receptors mediate nerve growth factor-stimulated calcium uptake.
MedLine Citation:
PMID:  9054365     Owner:  NLM     Status:  MEDLINE    
Human p140(trk) and p75(NGFR) were transfected separately into 3T3 cells. Nerve growth factor stimulates calcium uptake into both transfectants but not into untransfected 3T3 cells. p140(trk) cells were stimulated maximally by 25 ng/ml; 100 ng/ml was submaximal for p75(NGFR) cells. K-252a inhibits the effect of NGF on p140(trk) cells but not on p75(NGFR) cells; brain-derived neurotrophic factor stimulates calcium uptake in p75(NGFR) cells but not in p140(trk) cells. The data suggest that both nerve growth factor receptors could be involved in the nerve growth factor-mediated actions of calcium on its target cells: neuronal survival, neuronal protection, and synaptic plasticity.
H Jiang; D S Ulme; G Dickens; A Chabuk; M Lavarreda; P Lazarovici; G Guroff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  272     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-17     Completed Date:  1997-04-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6835-7     Citation Subset:  IM    
Section on Growth Factors, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
3T3 Cells
Calcium / metabolism*
Gene Transfer Techniques
Nerve Growth Factors / metabolism*,  pharmacology
Proto-Oncogene Proteins / agonists,  genetics,  metabolism*
Receptor Protein-Tyrosine Kinases / agonists,  genetics,  metabolism*
Receptor, Nerve Growth Factor
Receptor, trkA
Receptors, Nerve Growth Factor / agonists,  genetics,  metabolism*
Signal Transduction*
Reg. No./Substance:
0/Nerve Growth Factors; 0/Proto-Oncogene Proteins; 0/Receptor, Nerve Growth Factor; 0/Receptors, Nerve Growth Factor; 7440-70-2/Calcium; EC Protein-Tyrosine Kinases; EC, trkA

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