Document Detail


Both p140(trk) and p75(NGFR) nerve growth factor receptors mediate nerve growth factor-stimulated calcium uptake.
MedLine Citation:
PMID:  9054365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human p140(trk) and p75(NGFR) were transfected separately into 3T3 cells. Nerve growth factor stimulates calcium uptake into both transfectants but not into untransfected 3T3 cells. p140(trk) cells were stimulated maximally by 25 ng/ml; 100 ng/ml was submaximal for p75(NGFR) cells. K-252a inhibits the effect of NGF on p140(trk) cells but not on p75(NGFR) cells; brain-derived neurotrophic factor stimulates calcium uptake in p75(NGFR) cells but not in p140(trk) cells. The data suggest that both nerve growth factor receptors could be involved in the nerve growth factor-mediated actions of calcium on its target cells: neuronal survival, neuronal protection, and synaptic plasticity.
Authors:
H Jiang; D S Ulme; G Dickens; A Chabuk; M Lavarreda; P Lazarovici; G Guroff
Related Documents :
7488165 - A new perspective on the inhibitory role of nitric oxide in sympathetic neurotransmission.
20559625 - Involvement of hsp70, a stress protein, in the resistance of long-term culture of pc12 ...
9092945 - Rac is required for growth cone function but not neurite assembly.
7763725 - Establishment of hprt-deficient cell lines from mouse neuroblastoma neuro-2a and rat ph...
9154155 - Cellular distribution of branched-chain amino acid aminotransferase isoenzymes among ra...
9150795 - Development of hydrogen peroxide (h2o2)-generating oxidases in chick organs with specia...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  272     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-17     Completed Date:  1997-04-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6835-7     Citation Subset:  IM    
Affiliation:
Section on Growth Factors, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3T3 Cells
Animals
Calcium / metabolism*
Gene Transfer Techniques
Humans
Mice
Nerve Growth Factors / metabolism*,  pharmacology
Proto-Oncogene Proteins / agonists,  genetics,  metabolism*
Receptor Protein-Tyrosine Kinases / agonists,  genetics,  metabolism*
Receptor, Nerve Growth Factor
Receptor, trkA
Receptors, Nerve Growth Factor / agonists,  genetics,  metabolism*
Signal Transduction*
Chemical
Reg. No./Substance:
0/Nerve Growth Factors; 0/Proto-Oncogene Proteins; 0/Receptor, Nerve Growth Factor; 0/Receptors, Nerve Growth Factor; 7440-70-2/Calcium; EC 2.7.10.1/Receptor Protein-Tyrosine Kinases; EC 2.7.10.1/Receptor, trkA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cloning and characterization of a novel human lysyl hydroxylase isoform highly expressed in pancreas...
Next Document:  Estradiol activates the prostate androgen receptor and prostate-specific antigen secretion through t...