| Both overall adiposity and abdominal adiposity increase blood viscosity by separate mechanisms. | |
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MedLine Citation:
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PMID: 22012831 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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While recent studies suggested that both general adiposity and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-to-hip ratio (WHR) in addition to body index mass (BMI) in assessing the risk of death, this issue remains cintroversial since most authors conclude that BMI explains almost all the obesity-related risk of diabetes and conary heart disease (CHD). We investigated the separate effects of BMI and WHR on blood rheology in 430 patients attending to a metabolic check-up and exhibiting all the spectrum of age (11-77 yr) and BMI (15-50 kg/m2). BMI and WHR are correlated to each other (r = 0.269; p = 0.009) and are both predictors of blood viscosity (BMI: r = 0.15516; p = 0.004; WHR: r = 0.3638; p = 0.03). However while looking at determinants of viscosity these correlations had not the same meaning. For BMI it was explained by its correlation with plasma viscosity (r = 0.17718; p = 0.00105) and red blood cells (RBC) aggregation (all Myrenne and SEFAM indices with r ranging between 0.226 and 0.430) while these parameters were not correlated to WHR. By contrast WHR was strongly correlated with hematocrit (r = 0.524; p = 0.0003) which was not correlated with BMI. A forward stepwise regression selected WRH as a better predictor of blood viscosity, excluding BMI. Thus both BMI and WHR are associated with increased blood viscosity but these correlations reflect separate mechanisms. These data suggest that both overall adiposity and abdominal adiposity induce hyperviscosity, consistent with epidemiological studies linking the risk of CHD to abdominal adiposity and BMI. |
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Authors:
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Jean-Frédéric Brun; Emmanuelle Varlet-Marie; Eric Raynaud de Mauverger; Jacques Mercier |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical hemorheology and microcirculation Volume: 48 ISSN: 1875-8622 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
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Languages: eng Pagination: 257-63 Citation Subset: IM |
Affiliation:
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Physiopathologie & Médecine Expérimentale du Coeur et des Muscles INSERM U1046, Unité d'Explorations Métaboliques (CERAMM), Service Central de Physiologie Clinique, et Consultation d'Endocrinologie, Hôpital Lapeyronie CHU Montpellier, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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