| Both obesity-prone and obesity-resistant rats present delayed cutaneous wound healing. | |
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MedLine Citation:
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PMID: 21806853 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Diet-induced overweight rats exhibit delayed cutaneous healing; however, when receiving an obesogenic diet, some rats are susceptible to developing the overweight phenotype, whereas others are resistant. We investigated cutaneous healing in diet-induced obesity (DIO)-prone and diet-resistant (DR) rats. Male rats were fed with a standard (control) or a high-saturated fat (30 % fat, w/w) diet for 20 weeks. Then, the experimental group was subdivided into DIO (n 17) and DR (n 16) groups. An excision lesion was made, and the animals were killed 7 or 14 d later. The average body weight was 29 and 25 % higher in the DIO group compared with the C and DR groups. Retroperitoneal fat was higher in the DIO group than in the control and DR groups (518 and 92 %) and was higher in the DR group than in the control group (223 %). The DIO group presented glucose intolerance, and both the DIO and DR groups presented delayed wound contraction (50 %) and re-epithelialisation (20 %). Compared with the DR group, the DIO group displayed higher amounts of inflammatory cells as well as higher levels of lipid peroxidation (P < 0·05). Myofibroblastic differentiation and vessel remodelling were delayed in both the DIO and DR groups. Nitrite levels were lower in the DIO group (340 % less) than in the DR group. TNF-α expression was increased in the DIO group (130 %) compared with the DR group. Our results showed that DIO as well as DR rats present delays in cutaneous wound healing, even though the DR group does not have an overweight phenotype. |
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Authors:
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Adriana Paulino do Nascimento; Andréa Monte-Alto-Costa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of nutrition Volume: 106 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 603-11 Citation Subset: IM |
Affiliation:
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Tissue Repair Laboratory, Histology and Embryology Department, State University of Rio de Janeiro, Rua Professor Manuel de Abreu, 444, 3° Andar, 20550-170 Rio de Janeiro, RJ, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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