Document Detail

Both mild hypothermia and dopamine D(2) agonist are neuroprotective against hyperthermia-induced injury in PC12 cells.
MedLine Citation:
PMID:  18692549     Owner:  NLM     Status:  MEDLINE    
We exposed rat pheochromocytoma PC12 cells to hyperthermia or high dosage of dopamine and examined the direct effects of mild hypothermia or dopamine D(2) receptor agonist. At a hyperthermia of 42-43 degrees C for 120 min there was approximately 50% loss of cell viability accompanied by dopamine overproduction. The model of cell death due to hyperthermia in PC12 cells belonged to the necrotic and late apoptotic population. At each temperature examined below 37 degrees C, significant decrease in cytotoxicity, the percentage of necrotic and late apoptotic cells, and dopamine overproduction were observed. Cytotoxicity could also be induced by high dosages of dopamine. Both hyperthermia and dopamine induced cytotoxicity in PC12 cells could also be reduced by dopamine D(2) agonists. These results indicate the dopamine is important in hyperthermic situations. The results also indicate that mild hypothermia and dopamine D(2) receptor agonists are neuroprotective against hyperthermia-induced brain injury.
Bor-Chih Cheng; Ching-Ping Chang; Wen-Pin Liu; Mao-Tsun Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-03
Journal Detail:
Title:  Neuroscience letters     Volume:  443     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-02     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  140-4     Citation Subset:  IM    
Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
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MeSH Terms
Analysis of Variance
Annexin A5 / metabolism
Benzazepines / pharmacology
Cell Line, Transformed
Cell Survival / drug effects
Dopamine / metabolism
Dopamine Agonists / administration & dosage*
Dopamine Antagonists / pharmacology
Dopamine beta-Hydroxylase / metabolism
Dose-Response Relationship, Drug
Fever / therapy*
Hypothermia, Induced / methods*
Lisuride / pharmacology
Neuroprotective Agents / administration & dosage*
PC12 Cells
Time Factors
Reg. No./Substance:
0/Annexin A5; 0/Benzazepines; 0/Dopamine Agonists; 0/Dopamine Antagonists; 0/Neuroprotective Agents; 18016-80-3/Lisuride; EC beta-Hydroxylase

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