Document Detail

Both hypothyroidism and hyperthyroidism enhance low density lipoprotein oxidation.
MedLine Citation:
PMID:  9329379     Owner:  NLM     Status:  MEDLINE    
Hypothyroidism is frequently associated with hypercholesterolemia and an increased risk for atherosclerosis, whereas hyperthyroidism is known to precipitate angina or myocardial infarction in patients with underlying coronary heart disease. We have shown previously that L-T4 functions as an antioxidant in vitro and inhibits low density lipoprotein (LDL) oxidation in a dose-dependent fashion. The present study was designed to evaluate the changes in LDL oxidation in subjects with hypothyroidism and hyperthyroidism. Fasting blood samples for LDL oxidation analyses, lipoprotein determinations, and thyroid function tests were collected at baseline and after the patients were rendered euthyroid. The lag phase (mean +/- SEM hours) of the Cu+2-catalyzed LDL oxidation in the hypothyroid state and the subsequent euthyroid states were 4 +/- 0.0.65 and 14 +/- 0.68 h, respectively (P < 0.05). The lag phase during the hyperthyroid phase was 6 +/- 0.55 h, and that during the euthyroid phase was 12 +/- 0.66 h (P < 0.05). The total and LDL cholesterol levels were higher in hypothyroidism than in euthyroidism and were lower in hyperthyroidism than in the euthyroid state. We conclude that LDL has more susceptibility to oxidation in both the hypothyroid and hyperthyroid states. Thus, the enhanced LDL oxidation may play a role in the cardiac disease process in both hypothyroidism and hyperthyroidism.
V Sundaram; A N Hanna; L Koneru; H A Newman; J M Falko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  82     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-17     Completed Date:  1997-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3421-4     Citation Subset:  AIM; IM    
Department of Internal Medicine, Ohio State University, Columbus 43210, USA.
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MeSH Terms
Copper / pharmacology
Drug Resistance
Hyperthyroidism / blood*
Hypothyroidism / blood*
Lipoproteins / blood
Lipoproteins, LDL / blood*
Middle Aged
Reference Values
Time Factors
Reg. No./Substance:
0/Lipoproteins; 0/Lipoproteins, LDL; 7440-50-8/Copper
Comment In:
J Clin Endocrinol Metab. 1998 Sep;83(9):3377-8   [PMID:  9745459 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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