| Both human immunodeficiency virus-infected and human immunodeficiency virus-exposed, uninfected children living in Brazil, Argentina, and Mexico have similar rates of low concentrations of retinol, beta-carotene, and vitamin E. | |
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MedLine Citation:
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PMID: 19917451 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our objective was to describe the prevalence of low concentrations of retinol, beta-carotene, and vitamin E in a group of human immunodeficiency virus (HIV)-infected Latin American children and a comparison group of HIV-exposed, uninfected children. Our hypothesis was that the rates of low concentrations of these micronutrients would be higher in the HIV-infected group than those in the HIV-exposed, uninfected group. This was a cross-sectional substudy of a larger cohort study at clinical pediatric HIV centers in Latin America. Serum levels of micronutrients were measured in the first stored sample obtained after each child's first birthday by high-performance liquid chromatography. Low concentrations of retinol, beta-carotene, and vitamin E were defined as serum levels below 0.70, 0.35, and 18.0 micromol/L, respectively. The population for this analysis was 336 children (124 HIV-infected, 212 HIV-exposed, uninfected) aged 1 year or older to younger than 4 years. Rates of low concentrations were 74% for retinol, 27% for beta-carotene, and 89% for vitamin E. These rates were not affected by HIV status. Among the HIV-infected children, those treated with antiretrovirals were less likely to have retinol deficiency, but no other HIV-related factors correlated with micronutrient low serum levels. Low concentrations of retinol, beta-carotene, and vitamin E are very common in children exposed to HIV living in Brazil, Argentina, and Mexico, regardless of HIV-infection status. |
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Authors:
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Jacqueline P Monteiro; Laura Freimanis-Hance; Lidiane B Faria; Marisa M Mussi-Pinhata; James Korelitz; Hélio Vannucchi; Wladimir Queiroz; Regina C M Succi; Rohan Hazra |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Nutrition research (New York, N.Y.) Volume: 29 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-11-17 Completed Date: 2010-03-04 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
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Languages: eng Pagination: 716-22 Citation Subset: IM |
Affiliation:
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University of São Paulo, Ribeirão Preto, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anti-Retroviral Agents / therapeutic use Argentina Avitaminosis / blood, complications, epidemiology* Brazil Child Child, Preschool Cross-Sectional Studies HIV* HIV Infections / blood*, complications Humans Infant Mexico Micronutrients / blood* Prevalence Prospective Studies Vitamin A / blood* Vitamin A Deficiency / blood, complications, epidemiology Vitamin E / blood* Vitamin E Deficiency / blood, complications, epidemiology beta Carotene / blood* |
| Grant Support | |
ID/Acronym/Agency:
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N01-DK-80001/DK/NIDDK NIH HHS; N01-HD-33345/HD/NICHD NIH HHS; Z99 HD999999/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Retroviral Agents; 0/Micronutrients; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 7235-40-7/beta Carotene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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