| Both central command and exercise pressor reflex activate cardiac sympathetic nerve activity in decerebrate cats. | |
| | |
MedLine Citation:
|
PMID: 19234088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Both static and dynamic exercise are known to increase cardiac pump function as well as arterial blood pressure. Feedforward control by central command and feedback control by the exercise pressor reflex are thought to be the neural mechanisms causing these effects during exercise. It remains unknown as to how each mechanism activates cardiac sympathetic nerve activity (CSNA) during exercise, especially at its onset. Thus we examined the response of CSNA to stimulation of the mesencephalic locomotor region (MLR, i.e., central command) and to static muscle contraction of the triceps surae muscles or stretch of the calcaneal tendon in decerebrate cats. We found that MLR stimulation immediately increased CSNA, which was followed by a gradual increase in heart rate, mean arterial pressure, and ventral root activity in a stimulus intensity-dependent manner. The latency of the increase in CSNA from the onset of MLR stimulation ranged from 67 to 387 ms. Both static contraction and tendon stretch also rapidly increased CSNA. Their latency from the development of tension in response to ventral root stimulation ranged from 78 to 670 ms. These findings suggest that both central command and the muscle mechanoreflex play a role in controlling cardiac sympathetic outflow at the onset of exercise. |
| | |
Authors:
|
Hirotsugu Tsuchimochi; Shawn G Hayes; Jennifer L McCord; Marc P Kaufman |
Related Documents
:
|
20952768 - Influence of cardiomegaly on disordered breathing during exercise in chronic heart fail... 6140278 - Changes in cardiac functional capacity after coronary bypass surgery in relation to ade... 6264558 - Role of chemosensitivity during exercise in normal subjects and patients with pulmonary... 15487268 - Comparison of hemodynamics during hyperthermal immersion and exercise testing in appare... 8143688 - Evaluation of serum lactate dehydrogenase activity for estimation of energy expenditure... 16954128 - A pilot study on the effects of pre-event manipulation on jump height and running veloc... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-02-20 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 296 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-03-31 Completed Date: 2009-06-10 Revised Date: 2010-09-23 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H1157-63 Citation Subset: IM |
Affiliation:
|
Penn State Heart and Vascular Inst., 500 University Dr., Mail Code H047, Hershey Medical Ctr., Hershey, PA 17033, USA. htsuchimochi@hmc.psu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / physiology* Cats Central Nervous System / physiology* Decerebrate State / physiopathology* Heart / innervation*, physiology Locomotion / physiology Mechanoreceptors / physiology Mesencephalon / physiology Models, Animal Muscle Contraction / physiology Physical Conditioning, Animal / physiology* Pressoreceptors / physiology Sympathetic Nervous System / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
AR-051503/AR/NIAMS NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: PKA phosphorylation of HERG protein regulates the rate of channel synthesis.
Next Document: Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myo...