| Both Purkinje cells and left ventricular posteroseptal reentry contribute to the maintenance of ventricular fibrillation in open-chest dogs and swine: effects of catheter ablation and the ventricular cut-and-sew operation. | |
| | |
MedLine Citation:
|
PMID: 18577833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Radiofrequency catheter ablation (RFCA) targeting the left ventricular posteroseptum (LVPS) and posterior papillary muscle (PPM) terminates or prevents ventricular fibrillation (VF) in rabbit and dog hearts. However, whether the mechanism of VF maintenance is reentry or focal Purkinje firing is unclear. METHODS AND RESULTS: In the present study the effects of RFCA (endocardial ablation of PPM+LVPS in 7 dogs and 7 swine), left ventricular anterolateral wall ablation (LVAL in 7 dogs), and the cut-and-sew operation (CSO: along the left ventricular posterior wall (LVPW) beside PPM in 7 swine) on VF inducibility were compared. (1) VF inducibility was decreased from 100+/-0% to 21.9+/-31.2% (p<0.0001) by PPM+LVPS endocardial ablation, but not by LVAL ablation in dogs. (2) LVPW CSO reduced VF inducibility (100+/-0% to 43.6+/-9.5%, p<0.0001) in swine. (3) In contrast to the canine Purkinje network, which is mostly localized to the subendocardium, the swine Purkinje network extends to the subepicardial layer with a higher density (p<0.001). CONCLUSION: Both PPM+LVPS ablation (Purkinje destruction) in dogs and LVPW CSO (blocking reentry) in swine reduce VF inducibility, suggesting that in both species focal firing from the Purkinje network and reentry around the PPM contributes to the maintenance of VF. |
| | |
Authors:
|
Hui-Nam Pak; Gwang Il Kim; Hong Euy Lim; Yong Hu Fang; Jong Il Choi; Jin Seok Kim; Chun Hwang; Young-Hoon Kim |
Related Documents
:
|
8781153 - Transfemoral repositioning of malpositioned central venous catheters. 10667513 - How much guidewire is too much? direct measurement of the distance from subclavian and ... 4061963 - Two pumps and one heart: studies and theoretic considerations. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 72 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-06-25 Completed Date: 2008-09-18 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
|
Languages: eng Pagination: 1185-92 Citation Subset: IM |
Affiliation:
|
Korea University Cardiovascular Center, Seoul. yhkim@unitel.co.kr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Catheter Ablation* Disease Models, Animal Dogs Electrocardiography Endocardium / cytology Heart Septum / cytology, physiology, surgery Heart Ventricles / cytology, surgery Myocardium / cytology Papillary Muscles / cytology, physiology, surgery Purkinje Fibers / cytology, physiology*, surgery* Species Specificity Swine Ventricular Fibrillation / physiopathology*, surgery* Ventricular Function |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of HMGB1 on ischemia-reperfusion injury in the rat heart.
Next Document: Benefit of adding pioglitazone to successful statin therapy in nondiabetic patients with coronary ar...