| Both MK801 and NBQX reduce the neuronal damage after impact-acceleration brain injury. | |
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MedLine Citation:
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PMID: 12490009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To understand the pathogenesis of diffuse axonal injury, we investigated the temporal and spatial profiles of neuronal degeneration in impact-acceleration injury in rats using Fluoro-Jade (FJ) staining. Impact-acceleration injury was produced in Wistar rats by the method described by Marmarou et al. with some modifications. Animals were sacrificed 1, 2, 7, 14, or 28 days after injury. Paraffin-embedded coronal sections were stained with HE or FJ, or analyzed immunohistochemically for GFAP or amyloid precursor protein (APP). FJ-positive degenerative neurons were found primarily in the dorsal brainstem and thalamus from 1 to 2 days following injury and these were associated with GFAP expression. However, FJ-positive cells were rarely found after 7 days. In all rats, significant expression of APP was observed primarily in the cingulum, cerebral peduncle and pontomedullary junction. FJ also stained these injured axons. Intrathecal administration of both NMDA and AMPA/kinate glutamate receptor antagonists MK-801 and NBQX, respectively, reduced the neuronal injury. NBQX showed more significant effects on axonal injury than MK-801. These observations indicate that not only axonal damage, but also primary neuronal damage occurs in this impact-acceleration injury model. It is also suggested that NBQX can act both directly on neuronal cells and white matter and that NMDA could have a significant protective effect against not only neuronal, but also axonal injury. |
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Authors:
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Makoto Goda; Mitsuo Isono; Minoru Fujiki; Hidenori Kobayashi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurotrauma Volume: 19 ISSN: 0897-7151 ISO Abbreviation: J. Neurotrauma Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-12-19 Completed Date: 2003-01-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: United States |
Other Details:
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Languages: eng Pagination: 1445-56 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Oita Medical University, Oita, Japan. goda@oita.med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyloid beta-Protein Precursor
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biosynthesis Animals Brain Injuries / drug therapy*, metabolism, pathology Brain Stem / drug effects, metabolism, pathology Dizocilpine Maleate / pharmacology*, therapeutic use Glial Fibrillary Acidic Protein / biosynthesis Male Neurons / drug effects*, metabolism, pathology* Quinoxalines / pharmacology*, therapeutic use Rats Rats, Wistar Thalamus / drug effects, metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein Precursor; 0/Glial Fibrillary Acidic Protein; 0/Quinoxalines; 118876-58-7/2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; 77086-22-7/Dizocilpine Maleate |
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