| Both El Tor and classical cholera toxin bind blood group determinants. | |
| | |
MedLine Citation:
|
PMID: 22305717 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Cholera is a disease which shows a clear blood group profile, with blood group O individuals experiencing the most severe symptoms. For a long time, the cholera toxin has been suspected to be the main culprit of this blood group dependence. Here, we show that both El Tor and classical cholera toxin B-pentamers do indeed bind blood group determinants (with equal affinities), using Surface Plasmon Resonance and NMR spectroscopy. Together with previous structural data, this confirms our earlier hypothesis as to the molecular basis of cholera blood group dependence, with an interesting twist: the shorter blood group H-determinant characteristic of blood group O individuals binds with similar binding affinity compared to the A-determinant, however, with different kinetics. |
| | |
Authors:
|
Julie E Heggelund; Espen Haugen; Birgitte Lygren; Alasdair Mackenzie; Asa Holmner; Francesca Vasile; José J Reina; Anna Bernardi; Ute Krengel |
Related Documents
:
|
22382737 - Visualization of microscale particle focusing in diluted and whole blood using particle... 3115117 - Bulk flow of cerebrospinal fluid into brain in response to acute hyperosmolality. 22375087 - Blood and war. 21081957 - Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus o... 7073057 - Effects of dexamethasone on endotoxin shock in the anesthetized pony: hematologic, bloo... 2557067 - Novel mechanical assistance in the treatment of endotoxic and septicemic shock. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-28 |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: - ISSN: 1090-2104 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
|
Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, NO-0315 Oslo, Norway; Department of Molecular Biosciences, University of Oslo, P.O. Box 1041, Blindern, NO-0316 Oslo, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate a...
Next Document: Insights into the mechanisms mediating hyperglycemic and stressogenic outcomes in rats treated with ...