Document Detail

Bosentan and sildenafil: successful treatment in a sclerodermic patient with refractory ulcers.
MedLine Citation:
PMID:  23877412     Owner:  NLM     Status:  In-Data-Review    
Systemic sclerosis is an inflammatory disease of the connective tissue characterized by vasculopathy and accumulation of collagen and other components of the connective matrix, affecting the skin and internal organs. The appearance of skin ulcers as a result of vascular damage is very common in the history of the disease. Skin ulcers, painful and slow healing due to atrophy and local ischemia, get worse the quality of life of patients. Often, the use of conventional therapies (such as calcium channel blockers and prostanoids) does not cause the complete healing of the lesions. We report the case of a patient in whom therapeutic association between endothelin antagonist (bosentan) and phosphodiesterase-V inhibitor (sildenafil) resulted in complete healing of old ulcers both to upper and lower limbs and allowed the interruption of intravenous therapies.
E Catarsi; M Doveri; A Tavoni
Publication Detail:
Type:  Journal Article     Date:  2013-05-27
Journal Detail:
Title:  Reumatismo     Volume:  65     ISSN:  0048-7449     ISO Abbreviation:  Reumatismo     Publication Date:  2013  
Date Detail:
Created Date:  2013-07-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401302     Medline TA:  Reumatismo     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  79-81     Citation Subset:  IM    
U.O. Immunoallergologia, Ospedale S. Chiara, Pisa.
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