| Bosentan increases myocardial perfusion and function in systemic sclerosis: a magnetic resonance imaging and Tissue-Doppler echography study. | |
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MedLine Citation:
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PMID: 17080515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the short-term effects of bosentan on myocardial perfusion and function assessed by cardiac magnetic resonance imaging (MRI) and Tissue-Doppler echography (TDE) respectively in patients with systemic sclerosis (SSc). METHODS: We prospectively evaluated 18 SSc patients without clinical heart failure and with normal pulmonary arterial pressure. MRI perfusion index and systolic and diastolic strain rates (SR) determined by TDE were assessed at baseline for comparison with healthy controls (after a 72-hour vasodilator washout period), and repeated after 4 weeks of bosentan treatment (62.5 mg bid for 2 weeks titrated to 125 mg bid for 2 weeks). RESULTS: Patients with SSc had decreased MRI perfusion index and TDE SR in comparison with healthy controls. Bosentan treatment led to a significant increase in median (range) global MRI perfusion index [from 0.17 (0.09-0.23) at Day 0 to 0.22 (0.13-0.30) after bosentan treatment; p = 0.0004], systolic SR [from 2.1 (1.3-3.1) s-1 to 2.8 (2.1-4.8) s-1; p = 0.0002), and diastolic SR [from 2.6 (1.4-6.7) to 3.6 (2.0-7.6) s-1; p = 0.0003]. CONCLUSION: Short-term treatment with bosentan simultaneously improves myocardial perfusion and function, as evaluated by highly sensitive and quantitative methods, in patients with SSc. Whether additional remodeling effect may be observed after longterm treatment with bosentan remains to be determined. |
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Authors:
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Yannick Allanore; Christophe Meune; Olivier Vignaux; Simon Weber; Paul Legmann; Andre Kahan |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2006-10-15 |
Journal Detail:
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Title: The Journal of rheumatology Volume: 33 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-04 Completed Date: 2007-03-01 Revised Date: 2013-06-18 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: Canada |
Other Details:
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Languages: eng Pagination: 2464-9 Citation Subset: IM |
Affiliation:
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Services de Rhumatologie A, Cardiologie, and Radiologie A, Université Paris-Descartes, Faculté de Médecine, Hôpital Cochin, Paris, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use* Blood Pressure / drug effects Coronary Circulation / drug effects* Echocardiography, Doppler / methods Heart / drug effects*, physiology Humans Magnetic Resonance Imaging / methods Middle Aged Myocardial Contraction / drug effects*, physiology Scleroderma, Systemic / drug therapy*, pathology, physiopathology Sulfonamides / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Sulfonamides; Q326023R30/bosentan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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