| Bosentan in Clinical Practice for Treating Digital and Other Ischemic Ulcers in Spanish Patients with Systemic Sclerosis: IBER-DU Cohort Study. | |
| | |
MedLine Citation:
|
PMID: 21632679 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To describe treatment outcomes and safety experience with bosentan in patients with systemic sclerosis (SSc) and digital ulcers (DU), in a clinical setting in Spain. METHODS: This was a multicenter, noninterventional retrospective cohort study. Data were collected retrospectively from patients with DU, with or without pulmonary arterial hypertension (PAH), who were initiating bosentan therapy in 2003 (n = 26) or 2004 (n = 41) and followed until May 2005. Data were obtained from centers prescribing bosentan. Relevant measures included number of DU, occurrence of new DU, overall DU clinical status (improved, stabilized, worsened), and bosentan-associated adverse events. RESULTS: Sixty-seven patients with SSc and DU or other ulcers were included. PAH was also present in 12 patients (18%). At the start of bosentan treatment, the median number of DU per patient was 3.0. The median change in number of DU was -3.6 and -5.0 at 12 and 24 months, respectively. Sixty-eight percent of the patients did not develop any new DU at 12 months. DU clinical status was reported at 12 months for 22 patients: 18 patients (81.8%) improved and 4 (18.2%) stabilized. The median treatment duration was 13.0 months. The main adverse event was increase of aminotransferase, observed in 5 patients (7%), leading to discontinuation of treatment in 3 patients (4.4%). CONCLUSION: Previously reported results of bosentan efficacy in DU management are reproducible in clinical practice. This efficacy is maintained in the longterm followup. Bosentan treatment was well tolerated and adverse events were comparable with those observed in previous reports. |
| | |
Authors:
|
José Andrés Roman Ivorra; Carmen Pilar Simeon; Juan José Alegre Sancho; Maria Victoria Egurbide; Maria Jesús Castillo; Xavier Lloria; Vicent Fonollosa |
Related Documents
:
|
21756549 - Ct-based intravenous thrombolysis 3-4·5 hours after acute ischemic stroke in clinical ... 21622219 - Effect of thymectomy on cellular immune function. 22086879 - Treatment of unexplained syncope: a multicenter, randomized trial of cardiac pacing gui... 22207509 - Asymmetric pattern of cerebrovascular lesions in patients after left ventricular assist... 21967909 - The effectiveness and cost of passive warming in adult ambulatory surgery patients. 22186499 - Prosthesis salvage in breast reconstruction patients with periprosthetic infection and ... 21756549 - Ct-based intravenous thrombolysis 3-4·5 hours after acute ischemic stroke in clinical ... 17991169 - Evolution of helicobacter pylori research as observed through the workshops of the euro... 21622219 - Effect of thymectomy on cellular immune function. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-1 |
Journal Detail:
|
Title: The Journal of rheumatology Volume: - ISSN: 0315-162X ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the Rheumatology Department, Hospital Universitario La Fe, Valencia; Department of Internal Medicine, Hospital Vall d'Hebron, Vall d'Hebron; Actelion Pharmaceuticals S.L., Barcelona; Department of Internal Medicine, Hospital de Cruces, Bizkaia; and Department of Internal Medicine, Hospital Virgen del Rocío, Seville, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pain Mechanisms in Osteoarthritis: Understanding the Role of Central Pain and Current Approaches to ...
Next Document: Implantable Cardioverter Defibrillator Prevents Sudden Cardiac Death in Systemic Sclerosis.