| Bosentan does not improve pulmonary hypertension and lung remodeling in heart failure. | |
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MedLine Citation:
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PMID: 20595149 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Pulmonary hypertension (PH) and right ventricular (RV) dysfunction associated with heart failure (HF) carry a poor prognosis. Although endothelin receptor antagonists (ERAs) demonstrated benefits in pulmonary arterial hypertension, their efficacy in PH associated with HF was not specifically evaluated. 2 weeks after myocardial infarction (MI) rats received bosentan (100 or 200 mg·kg(-1)·day(-1)) or no treatment for 3 weeks. PH, RV hypertrophy and function as well as lung remodeling and function were evaluated. LV echocardiographic wall motion abnormality and function measured before treatment (2 weeks after MI) and after treatment (5 weeks after MI) were similar in MI control and MI treatment groups. HF induced PH and RV hypertrophy compared with sham: RV systolic pressure 39±5 versus 23±0.8 mmHg and RV/left ventricular+septum weight 52±7 versus 24±0.5% (all p<0.01). Bosentan did not significantly modify these parameters. In addition, bosentan did not improve depressed RV function measured by echocardiograph from the RV myocardial performance index and tricuspid annular plane systolic excursion. The respiratory pressure-volume relationship revealed that HF caused a restrictive lung syndrome with histological lung remodeling and fibrosis, also not improved by bosentan. Dual ERA therapy with bosentan does not reduce PH, RV hypertrophy and lung remodeling and dysfunction associated with ischaemic HF. |
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Authors:
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B H Jiang; J-C Tardif; Y Shi; J Dupuis |
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Publication Detail:
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Type: Journal Article Date: 2010-07-01 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 37 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 578-86 Citation Subset: IM |
Affiliation:
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Research Center, Montreal Heart Institute and Dept of Medicine, Université de Montréal, 5000 Belanger Street, Montreal, Quebec H1T 1C8, Canada. E-mail: jocelyn.dupuis@bellnet.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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